Structure-based Drug Design • Multiparameter lead optimization • SAR-analysis • process development • Total synthesis • HPLC • NMR • Mass spectromery • and computer skills • and people mangement skills
Daniel P. Getman - Chesterfield MO Gary A. DeCrescenzo - St. Charles MO John N. Freskos - Clayton MO Michael L. Vazquez - Gurnee IL James A. Sikorski - Des Peres MO Balekudru Devadas - Chesterfield MO Joseph J. McDonald - Ballwin MO
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
Daniel P Getman - Chesterfield MO Gary A DeCrescenzo - St. Peters MO John N Freskos - Clayton MO Michael L Vazquez - Ballwin MO James A Sikorski - Des Peres MO Balekudru Devadas - Chesterfield MO Srinivasan Raj Nagarajan - Chesterfield MO David L Brown - Chesterfield MO Joseph J McDonald - Ballwin MO
Assignee:
G. D. Searle Co. - Chicago IL
International Classification:
C07C31103
US Classification:
564 92, 564 90, 514604
Abstract:
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
Daniel P Getman - Chesterfield MO Gary A DeCrescenzo - St. Peters MO John N Freskos - Clayton MO Michael L Vazquez - Gurnee MO James A Sikorski - Des Peres MO Balekudru Devadas - Chesterfield MO Srinivasan Nagarajan - Chesterfield MO David L Brown - Chesterfield MO Joseph J McDonald - Ballwin MO
Assignee:
G. D. Searle Co. - Chicago IL
International Classification:
A61K 314025
US Classification:
514422, 548526
Abstract:
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
Pyrazole Substituted Hydroxamic Acid Derivatives As Cyclooxygenase-2 And 5-Lipoxygenase Inhibitors
John J Talley - St. Louis MO James A Sikorski - Des Peres MO Matthew J Graneto - Chesterfield MO Jeffrey S Carter - Chesterfield MO Bryan H Norman - Indianapolis IN Balekudru Devadas - Chesterfield MO
Assignee:
Pharmacia Corporation - St.Louis MO
International Classification:
A61K 31415
US Classification:
514406, 5483751
Abstract:
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
Daniel P Getman - Chesterfield MO Gary A. DeCrescenzo - St. Peters MO John N. Freskos - Clayton MO Michael L. Vazquez - Ballwin MO James A. Sikorski - Des Peres MO Balekudru Devadas - Chesterfield MO Srinivasan Nagarajan - Chesterfield MO David L. Brown - Chesterfield MO Joseph J. McDonald - Ballwin MO
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
Substituted Benzopyran Analogs For The Treatment Of Inflammation
Jeffery S Carter - Chesterfield MO Mark G Obukowicz - Kirkwood MO Balekudru Devadas - Chesterfield MO John J Talley - St. Louis MO David L Brown - Chesterfield MO Matthew J Graneto - Chesterfield MO Stephen R Bertenshaw - Cheshire CT Srinivasan Raj Nagarajan - Chesterfield MO Cathleen E Hanau - St. Louis MO Susan J Hartmann - Kirkwood MO Cindy L Ludwig - St. Louis MO Suzanne Metz - Chesterfield MO Donald E Korte - Mundelein IL
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula Iâ wherein X, A , A , A , A , R, Râ, R and R are as described in the specification.
Heterocyclo Substituted Hydroxamic Acid Derivatives As Cyclooxygenase-2 And 5-Lipoxygenase Inhibitors
John J Talley - St. Louis MO James A Sikorski - Des Peres MO Matthew J Graneto - Chesterfield MO Jeffrey S Carter - Chesterfield MO Bryan H Norman - Indianapolis IN Balekudru Devadas - Chesterfield MO
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
Thiophene Substituted Hydroxamic Acid Derivatives As Cyclooxygenase-2 And 5-Lipoxygenase Inhibitors
John J Talley - St. Louis MO James A Sikorski - Des Peres MO Matthew J Graneto - Chesterfield MO Jeffrey S Carter - Chesterfield MO Bryan H Norman - Indianapolis IN Balekudru Devadas - Chesterfield MO
Assignee:
G. D. Searle Co. - Chicago IL
International Classification:
C07D33324
US Classification:
514438, 549 77
Abstract:
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
Confluence Life sciences Inc St. Louis, MO 2010 to 2012 Science Research FellowPfizer St. Louis, MO 2004 to 2010 Associate FellowPharmacia, St. Louis, MO St. Louis, MO 1999 to 2004 Research AdvisorG. D. Searle St. Louis, MO 1996 to 1999 RESEARCH SCIENTIST IIG. D. Searle St. Louis, MO 1994 to 1995 RESEARCH SCIENTIST IMonsanto St. Louis, MO 1991 to 1993 Research SpecialistMonsanto St. Louis, MO 1987 to 1990 SENIOR RESEARCH CHEMISTUniv. of Illinois Urbana, IL 1985 to 1987 Postdoctoral Research AssociateProf. J. P. Ferris Troy, NY 1981 to 1984 Postdoctoral Research Associate
Education:
Central Drug Research Institute 1980 Ph. D. in Chemistry
Skills:
Structure-based Drug Design, Multiparameter lead optimization, SAR-analysis, process development, Total synthesis, HPLC, NMR,Mass spectromery,and computer skills,and people mangement skills
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