The present invention discloses a self-contained miniature DNA biosensor designed to detect specific molecular targets, particularly suitable for detection of nucleic acids. For example, hybridized DNA may be detected without external monitoring or signal transmission. The miniaturized biosensor is a biochip comprising multiple biological sensing elements such as DNA probes, excitation microlasers, a sampling waveguide equipped with optical detectors (fluorescence and Raman), integrated electro-optics, and a biotelemetric radio frequency signal generator. The novel integrated circuit biochip microsystem (ICBM) is suitable for gene analysis and will allow rapid, large-scale, and cost-effective production of gene biochips.
A monolithic sensor includes a reference channel and at least one sensing channel. Each sensing channel has an oscillator and a counter driven by the oscillator. The reference channel and the at least one sensing channel being formed integrally with a substrate and intimately nested with one another on the substrate. Thus, the oscillator and the counter have matched component values and temperature coefficients. A frequency determining component of the sensing oscillator is formed integrally with the substrate and has an impedance parameter which varies with an environmental parameter to be measured by the sensor. A gating control is responsive to an output signal generated by the reference channel, for terminating counting in the at least one sensing channel at an output count, whereby the output count is indicative of the environmental parameter, and successive ones of the output counts are indicative of changes in the environmental parameter.
Implantable Device For In-Vivo Intracranial And Cerebrospinal Fluid Pressure Monitoring
Milton N. Ericson - Knoxville TN Timothy E. McKnight - Greenback TN Stephen F. Smith - London TN James O. Hylton - Clinton TN
Assignee:
UT-Battelle, LLC - Oak Ridge TN
International Classification:
A61B 500
US Classification:
600561, 600300, 600486, 600587, 600128, 600903
Abstract:
The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.
Implant For In-Vivo Parameter Monitoring, Processing And Transmitting
Milton N. Ericson - Knoxville TN, US Timothy E. McKnight - Greenback TN, US Stephen F. Smith - London TN, US James O. Hylton - Clinton TN, US
Assignee:
UT-Battelle, LLC - Oak Ridge TN
International Classification:
A61B 5/00 A61B 5/103 A61B 5/117
US Classification:
600561, 600300, 600587, 128903
Abstract:
The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.
Method And Apparatus For Orthopedic Implant Assessment
Milton Ericson - Knoxville TN, US Charles Britton - Alcoa TN, US Justin Baba - Knoxville TN, US Robert Warmack - Knoxville TN, US
International Classification:
A61F 2/30 G01M 19/00 G01H 11/00
US Classification:
073649000, 073172000, 623914000
Abstract:
Methods and apparatus are described for orthopedic implant assessment. A method includes characterizing wear of an orthopedic implant including measuring a dimension in a direction that defines a path that passes through an articulating surface of a wear element of the orthopedic implant using at least one thickness sensor. An apparatus includes an orthopedic implant including a wear element having an articulating surface; and at least one thickness sensor coupled to the wear element, the at least one thickness sensor measuring a dimension in a direction that defines a path that passes through the articulating surface of the wear element. A method includes characterizing forces within an orthopedic implant including using a plurality of individually addressable pressure sensors including measuring parasitic impedance between at least two of the plurality of individually addressable pressure sensors.
Timothy E. McKnight - Greenback TN, US Anthony Johnson - Houston TX, US Milton Nance Ericson - Knoxville TN, US Justin S. Baba - Knoxville TN, US John B. Wilgen - Oak Ridge TN, US Boyd Mccutchen Evans, III - Oak Ridge TN, US
Assignee:
UT-BATTELLE, LLC - Oak Ridge TN BAYLOR COLLEGE OF MEDICINE - Houston TX
International Classification:
A61F 2/04 A61F 2/48
US Classification:
623 2368, 623 24
Abstract:
Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.
Tuan Vo-Dinh - Knoxville TN Alan Wintenberg - Knoxville TN Milton N. Ericson - Knoxville TN
Assignee:
UT-Battelle, LLC - Oak Ridge TN
International Classification:
C12Q 168 C12P 1934 C12N 900 C07H 2104
US Classification:
435 6
Abstract:
The present invention discloses a self-contained miniature DNA biosensor designed to detect specific molecular targets, particularly suitable for detection of nucleic acids. For example, hybridized DNA may be detected without external monitoring or signal transmission. The miniaturized biosensor is a biochip comprising multiple biological sensing elements such as DNA probes, excitation microlasers, a sampling waveguide equipped with optical detectors (fluorescence and Raman), integrated electrooptics, and a biotelemetric radio frequency signal generator. The novel integrated circuit biochip microsystem (ICBM) is suitable for gene analysis and will allow rapid, large-scale, and cost-effective production of gene biochips.
Electrical Meter Probe Contact Verification System
- Oak Ridge TN, US Milton Nance Ericson - Oak Ridge TN, US Roger A. Kisner - Oak Ridge TN, US Yarom Poisky - Oak Ridge TN, US
International Classification:
G01R 31/02 G01R 1/067 G01R 1/073
Abstract:
A system and method verifies continuity with and measures voltage across a circuit under test (in some instances simultaneously) using two or more test probes. Two or more probe continuity circuits measure continuity through the test probes by injecting a test current through and measuring a processed test current received at each of the plurality of test probes. The probe continuity circuits measure the respective processed test current rendered by the test current flowing through the test circuit at each test probe. A voltmeter measures the potential difference across the test probes.