Ellen Ann Panisko from 901 Bombing Range Rd, Richland, WA 99353, age 51, Phone: 5099673246

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Phosphoprotein Binding Agents And Methods Of Their Use
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US Patent:

20020119505, Aug 29, 2002
Filed:

Feb 16, 2001
Appl. No.:

09/788286
Inventors:

Michael Goshe - Richland WA, US
Thomas Conrads - Richland WA, US
Timothy Veenstra - West Richland WA, US
Ellen Panisko - West Richland WA, US
International Classification:

G01N033/537
G01N033/543
US Classification:

435/007920
Abstract:

The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein-protein interactions is provided.

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