Anton Y Agarkov

US Patent:

20090069248, Mar 12, 2009

Filed:

Sep 20, 2007

Appl. No.:

11/901978

Inventors:

Vladimir L. Motin - League City TX, US
Sadhana Chauhan - League City TX, US
Scott R. Gilbertson - Galveston TX, US
Anton Agarkov - Galveston TX, US
Pedro Lory - Antwerpen, BE

International Classification:

C12Q 1/37
C07K 7/06
A61K 38/02
A61K 38/06
A61K 38/07
A61K 38/08
C07K 5/08
C07K 5/10
A61P 31/04

US Classification:

514 17, 530331, 530330, 530329, 435 23, 514 18

Abstract:

The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes . Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.

US Patent:

20120045474, Feb 23, 2012

Filed:

Aug 29, 2011

Appl. No.:

13/199407

Inventors:

Vladimir L. Motin - League City TX, US
Sadhana Chauhan - Leauge City TX, US
Scott R. Gilbertson - Galveston TX, US
Anton Agarkov - Galveston TX, US
Pedro Lory - Antwerpen, BE

International Classification:

A61K 39/02
A61K 38/08
A61K 38/07
A61K 38/06
A61P 31/04
C40B 30/08
C07C 225/18
C07C 61/08
C07C 63/49
C07D 409/12
C07D 333/36
C07K 7/06
C07K 5/11
C07K 5/09
A61P 37/04
C12Q 1/37

US Classification:

4242341, 435 23, 514 201, 514 24, 506 11, 564342, 562500, 562492, 549 59, 549 69, 530329, 530330, 530331

Abstract:

The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes . Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.