Yiyang Liu

US Patent:

20130267699, Oct 10, 2013

Filed:

Mar 12, 2013

Appl. No.:

13/797736

Inventors:

Scott C. Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Temple City CA, US

International Classification:

C07D 265/32
C07D 207/16
C07D 223/10
C07D 211/60

US Classification:

540529, 546298, 546299, 548531, 544172

Abstract:

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II):comprising treating a compound of Formula (I):with a transition metal catalyst and under alkylation conditions as valence and stability permit.

US Patent:

20130012701, Jan 10, 2013

Filed:

Jun 22, 2012

Appl. No.:

13/531485

Inventors:

Brian M. Stoltz - San Marino CA, US
Scott C. Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Temple City CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C07D 211/78
C07D 207/277
C07D 223/10
C07D 265/32
C07D 309/08
C07D 309/30
C07D 207/36
C07D 241/08
C07D 223/04
C07F 7/18
C07C 229/00

US Classification:

540529, 546221, 546 14, 548536, 544172, 546205, 546203, 560 41, 549291, 546220, 544383, 540607, 549425, 546222

Abstract:

A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D.In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf are each independently hydrogen, a substituted or unsubstituted hydrocarbyl group, a substituted or unsubstituted heteroatom containing hydrocarbyl group, or a functional group; d, e and f are each independently 0 or greater; each of A, B and D is independently a carbon atom or a heteroatom; and two or more of R1 though R11, Ra through Rf and Y optionally combine to form a ring. In some embodiments, R8 and R9 combine to form a carbonyl group. In some embodiments, R2 and Y combine to form a ring with the Q atom. In some embodiments, the ring includes at least one double bond.

US Patent:

20230098847, Mar 30, 2023

Filed:

Jul 18, 2022

Appl. No.:

17/867233

Inventors:

- Pasadena CA, US
Scott C. Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Los Angeles CA, US

International Classification:

C07D 211/78
C07D 265/32
C07D 211/60
C07D 207/16
C07D 223/10
C07D 309/04
C07D 223/04
C07D 241/04
C07D 241/08
C07D 241/52
C07D 207/06
C07D 265/30
C07D 207/08
C07D 207/10
C07D 207/26
C07D 207/263
C07D 207/27
C07D 207/46
C07D 211/16
C07D 211/18
C07D 211/22
C07D 211/34
C07D 211/38
C07D 211/76
C07D 211/88
C07D 211/94
C07D 211/96
C07D 309/30
C07D 207/267
C07D 207/273
C07D 207/277
C07D 211/90

Abstract:

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II):comprising treating a compound of Formula (I):with a transition metal catalyst and under alkylation conditions as valence and stability permit.

US Patent:

20210155592, May 27, 2021

Filed:

Feb 1, 2021

Appl. No.:

17/164204

Inventors:

- Pasadena CA, US
Scott C. Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Los Angeles CA, US

International Classification:

C07D 211/78
C07D 265/32
C07D 211/60
C07D 207/16
C07D 223/10
C07D 309/04
C07D 223/04
C07D 241/04
C07D 241/08
C07D 241/52
C07D 207/06
C07D 265/30
C07D 207/08
C07D 207/10
C07D 207/26
C07D 207/263
C07D 207/27
C07D 207/46
C07D 211/16
C07D 211/18
C07D 211/22
C07D 211/34
C07D 211/38
C07D 211/76
C07D 211/88
C07D 211/94
C07D 211/96
C07D 309/30
C07D 207/267
C07D 207/273
C07D 207/277
C07D 211/90

Abstract:

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II):comprising treating a compound of Formula (I):with a transition metal catalyst and under alkylation conditions as valence and stability permit.

US Patent:

20200157049, May 21, 2020

Filed:

May 31, 2019

Appl. No.:

16/427629

Inventors:

- Pasadena CA, US
Scott C. Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Los Angeles CA, US

International Classification:

C07D 211/78
C07D 265/32
C07D 211/60
C07D 207/16
C07D 223/10
C07D 309/04
C07D 223/04
C07D 241/04
C07D 241/08
C07D 241/52
C07D 207/06
C07D 265/30
C07D 207/08
C07D 207/10
C07D 207/26
C07D 207/263
C07D 207/27
C07D 207/46
C07D 211/16
C07D 211/18
C07D 211/22
C07D 211/34
C07D 211/38
C07D 211/76
C07D 211/88
C07D 211/94
C07D 211/96
C07D 309/30
C07D 207/267
C07D 207/273
C07D 207/277
C07D 211/90

Abstract:

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II):comprising treating a compound of Formula (I):with a transition metal catalyst and under alkylation conditions as valence and stability permit.

US Patent:

20180339968, Nov 29, 2018

Filed:

Jul 30, 2018

Appl. No.:

16/049434

Inventors:

- Pasadena CA, US
Scott C. Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Los Angeles CA, US

International Classification:

C07D 211/78
C07D 223/10
C07D 309/04
C07D 207/16
C07D 211/60
C07D 211/90
C07D 207/277
C07D 207/273
C07D 207/267
C07D 309/30
C07D 211/96
C07D 211/94
C07D 211/88
C07D 211/76
C07D 211/38
C07D 211/34
C07D 211/22
C07D 211/18
C07D 211/16
C07D 207/46
C07D 207/27
C07D 207/263
C07D 207/26
C07D 207/10
C07D 207/08
C07D 265/30
C07D 207/06
C07D 241/52
C07D 241/08
C07D 241/04
C07D 223/04
C07D 265/32

Abstract:

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II):comprising treating a compound of Formula (I):with a transition metal catalyst and under alkylation conditions as valence and stability permit.

US Patent:

20170137382, May 18, 2017

Filed:

Dec 1, 2016

Appl. No.:

15/366590

Inventors:

- Pasadena CA, US
Scott C Virgil - Pasadena CA, US
David E. White - Wayne PA, US
Taiga Yurino - Kyoto, JP
Yiyang Liu - Pasadena CA, US
Douglas C. Behenna - Laguna Niguel CA, US
Douglas Duquette - Los Angeles CA, US

International Classification:

C07D 211/78
C07D 207/277
C07D 207/27
C07D 265/32
C07D 211/90
C07D 211/76
C07D 211/96
C07D 223/10

Abstract:

The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II):comprising treating a compound of Formula (I):with a transition metal catalyst and under alkylation conditions as valence and stability permit.