Xudong Ge

US Patent:

20080261255, Oct 23, 2008

Filed:

Mar 1, 2004

Appl. No.:

10/552164

Inventors:

Leah Tolosa - Columbia MD, US
Govind Rao - Columbia MD, US
Xudong Ge - Ellicott City MD, US

International Classification:

C12Q 1/48
G01N 21/76
G01N 33/00

US Classification:

435 15, 436172, 436106, 436 94, 436 95

Abstract:

A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors.

US Patent:

20100207035, Aug 19, 2010

Filed:

Jan 25, 2010

Appl. No.:

12/692752

Inventors:

Govind RAO - Columbia MD, US
Hung LAM - Baltimore MD, US
Yordan KOSTOV - Columbia MD, US
Leah TOLOSA - Columbia MD, US
Xudong GE - Ellicott City MD, US

International Classification:

G01N 21/64
G01J 1/58

US Classification:

2504581

Abstract:

A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.

US Patent:

20110273705, Nov 10, 2011

Filed:

Jan 25, 2010

Appl. No.:

13/142284

Inventors:

Govind Rao - Ellicott City MD, US
Hung Lam - Baltimore MD, US
Yordan Kostov - Columbia MD, US
Leah Tolosa - Columbia MD, US
Xudong Ge - Ellicott City MD, US

Assignee:

UNIVERSITY OF MARYLAND BALTIMORE COUNTY - Baltimore MD

International Classification:

G01J 1/42

US Classification:

356222

Abstract:

A low cost sensing system that can measure both chlorophyll concentration and turbidity is provided. The system is an optical system that utilizes at least three light sensors for measuring side-scattered and forward scattered light, as well as fluorescence. The system is able to take optical density measurements, steady state fluorescence measurements and maximum fluorescence measurements, and can be configured for wireless control and data transmission. The system may also be housed in one or more fluidtight housings so as to make it submersible.

US Patent:

20130253295, Sep 26, 2013

Filed:

Feb 4, 2013

Appl. No.:

13/758867

Inventors:

Leah TOLOSA - Columbia MD, US
Xudong GE - Ellicott City MD, US
Yordan KOSTOV - Columbia MD, US
Michael TOLOSA - Columbia MD, US
Govind RAO - Ellicott City MD, US

International Classification:

A61B 5/145

US Classification:

600365, 600309

Abstract:

Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.

US Patent:

20130280797, Oct 24, 2013

Filed:

Mar 8, 2012

Appl. No.:

13/823911

Inventors:

Govind Rao - Ellicott City MD, US
Yordan Kostov - Columbia MD, US
Leah Tolosa - Columbia MD, US
Lam Hung - Baltimore MD, US
Xudong Ge - Woodstock MD, US
Douglas Frey - Ellicott City MD, US
Virenda Singh - Baltimore MD, US

International Classification:

C12M 1/40

US Classification:

4352887, 4352941, 4352871

Abstract:

A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.

US Patent:

20130281806, Oct 24, 2013

Filed:

Sep 30, 2011

Appl. No.:

13/823903

Inventors:

Govind Rao - Ellicott City MD, US
Yordan Kostov - Columbia MD, US
Xudong Ge - Woodstock MD, US
Leah Tolosa - Crownsville MD, US
Hyung Woo - Baltimore MD, US
Rose Viscardi - Timonium MD, US

International Classification:

A61B 5/1455

US Classification:

600326, 600335

Abstract:

A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.

US Patent:

20220298469, Sep 22, 2022

Filed:

Jun 10, 2022

Appl. No.:

17/837772

Inventors:

- Baltimore MD, US
Yordan KOSTOV - Columbia MD, US
Leah TOLOSA - Columbia MD, US
Kevin TRAN - Marriotsville MD, US
Monohar Pilli - Gwynn Oak MD, US
Michael TOLOSA - Columbia MD, US
Chandrashekar Gurramkonda - Halethorpe MD, US
Xudong GE - Woodstock MD, US
Douglas Frey - Ellicott City MD, US

International Classification:

C12M 1/00
C07K 1/36
A61K 35/14
A61M 1/36
B01D 15/08
B01D 15/32
B01D 15/36
B01D 15/38
C12M 1/40

Abstract:

A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.

US Patent:

20210380915, Dec 9, 2021

Filed:

Aug 20, 2021

Appl. No.:

17/407392

Inventors:

- Baltimore MD, US
YORDAN KOSTOV - COLUMBIA MD, US
MICHAEL TOLOSA - COLUMBIA MD, US
XUDONG GE - WOODSTOCK MD, US
VIKASH KUMAR - CATONSVILLE MD, US

International Classification:

C12M 1/24
C12M 3/00
C12M 1/04
C12M 1/00
C12M 1/34

Abstract:

The present invention relates to collapsible and/or foldable fermentation and/or culture vessels fabricated of an adjustable frame including sections of gas permeable material or in the alternative a non-rigid gas permeable polymeric container or bag fabricated of either a gas permeable or non-gas permeable material with the further benefit of more efficient inventory space and disposal space, wherein the gas permeable material or non-gas permeable material comprises an analyte or pH sensing material integrated or impregnated into at least one section of the material.