William C Sessa

US Patent:

6900038, May 31, 2005

Filed:

Sep 20, 2001

Appl. No.:

09/956699

Inventors:

William C. Sessa - Madison CT, US

Assignee:

Yale University - New Haven CT

International Classification:

C12N009/02
C12N015/00
C07H021/04

US Classification:

435189, 435440, 536 232

Abstract:

The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and their encoding nucleic acid molecules are useful as gene therapy agents for the treatment of diseases including post angioplasty restenosis, hypertension, atherosclerosis, heart failure, diabetes and diseases with defective angiogenesis. NOS proteins and peptides are also useful in methods of screening for agents which modulate NOS activity.

US Patent:

7494976, Feb 24, 2009

Filed:

Feb 4, 2003

Appl. No.:

10/358365

Inventors:

William C. Sessa - Madison CT, US

Assignee:

Yale University - New Haven CT

International Classification:

A61K 38/00

US Classification:

514 12, 530324

Abstract:

The present invention relates generally to compositions and methods useful for treating various conditions and afflictions, such as inflammation and cancer. More specifically, the present invention relates to compositions and methods of treatment which utilize peptides comprising at least one caveolin scaffolding domain. Even more specifically, the present invention relates to compositions of fusion peptides comprising the antennapedia homeodomain fused to a caveolin scaffolding domain and to methods of using these peptides to treat various conditions and afflictions.

US Patent:

7767641, Aug 3, 2010

Filed:

Apr 23, 2004

Appl. No.:

10/554252

Inventors:

William C. Sessa - Madison CT, US
Lisette Acevedo - San Diego CA, US

Assignee:

Yale University - New Haven CT

International Classification:

A61K 38/17

US Classification:

514 2, 514 8, 514 12

Abstract:

The present invention relates to previously unknown biological roles of Nogo-B. We have discovered that Nogo-B is a component of endothelial cells. We have also discovered that Nogo-B is highly expressed in intact blood vessels. The amino terminus of Nogo-B promotes the adhesion, spreading and migration of endothelial cells and plays a role in vascular remodeling. Thus, Nogo-B is a novel regulator of vascular homeostasis and remodeling. The present invention provides compositions comprising Nogo-B and fragments and fusion proteins thereof. The present invention also relates to nucleic acids encoding Nogo-B and fragments and fusion proteins thereof, as well as vectors and cells comprising such nucleic acids. The present invention also relates to antibodies specific for Nogo-B and fragments and fusion proteins thereof. The present invention also provides methods for preventing, detecting and treating Nogo-B-related diseases, disorders and conditions.

US Patent:

7888089, Feb 15, 2011

Filed:

Dec 9, 2008

Appl. No.:

12/316128

Inventors:

William C. Sessa - Madison CT, US

Assignee:

Yale University - New Haven CT

International Classification:

C12N 9/02
C12N 1/20
C12N 15/00
C12P 21/04
C07H 21/04

US Classification:

435189, 435440, 435 691, 4352523, 4353201, 536 232

Abstract:

The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and their encoding nucleic acid molecules are useful as gene therapy agents for the treatment of diseases including post angioplasty restenosis, hypertension, atherosclerosis, heart failure, diabetes and diseases with defective angiogenesis. NOS proteins and peptides are also useful in methods of screening for agents which modulate NOS activity.

US Patent:

8084228, Dec 27, 2011

Filed:

Jan 12, 2007

Appl. No.:

12/087435

Inventors:

William C. Sessa - Madison CT, US
Quing Miao - New Berlin WI, US

Assignee:

Yale University - New Haven CT

International Classification:

C07K 14/435
C07H 21/04
C12N 5/00
C12N 7/01
C12N 15/09
C12P 21/02

US Classification:

435 691, 435 701, 4352351, 4353201, 435325, 530300, 530350, 536 235

Abstract:

Nogo-B receptors bind to Nogo-B and mediate its biological function. We have discovered that Nogo-B receptor is a component of endothelial cells, and is highly expressed in intact blood vessels. The present invention provides compositions comprising the Nogo-B receptor and fragments and fusion proteins thereof. The present invention also relates to nucleic acids encoding the Nogo-B receptor and fragments and fusion proteins thereof, as well as vectors and cells comprising such nucleic acids. The present invention also relates to antibodies specific for the Nogo-B receptor and fragments and fusion proteins thereof. The present invention also provides methods for preventing, detecting and treating Nogo-B receptor-related diseases, disorders and conditions.

US Patent:

8349798, Jan 8, 2013

Filed:

Oct 30, 2007

Appl. No.:

11/978770

Inventors:

William C. Sessa - Madison CT, US

Assignee:

Yale University - New Haven CT

International Classification:

A61K 38/00

US Classification:

514 12, 530324

Abstract:

The present invention relates generally to compositions and methods useful for treating various conditions and afflictions, such as inflammation and cancer. More specifically, the present invention relates to compositions and methods of treatment which utilize peptides comprising at least one caveolin scaffolding domain. Even more specifically, the present invention relates to compositions of fusion peptides comprising the antennapedia homeodomain fused to a caveolin scaffolding domain and to methods of using these peptides to treat various conditions and afflictions.

US Patent:

20020077283, Jun 20, 2002

Filed:

Dec 7, 2000

Appl. No.:

09/731023

Inventors:

William Sessa - Madison CT, US

International Classification:

A61K038/17
C12N009/99

US Classification:

514/012000, 435/184000

Abstract:

The present invention relates generally to compositions and methods useful for treating various conditions and afflictions, such as inflammation and cancer. More specifically, the present invention relates to compositions and methods of treatment which utilize peptides comprising at least one caveolin scaffolding domain. Even more specifically, the present invention relates to compositions of fusion peptides comprising the antennapedia homeodomain fused to a caveolin scaffolding domain and to methods of using these peptides to treat various conditions and afflictions.

US Patent:

20020164658, Nov 7, 2002

Filed:

Sep 14, 1998

Appl. No.:

09/142722

Inventors:

ROBERT M. WEISS - NORTH HAVEN CT, US
WILLIAM C. SESSA - MADISON CT, US
MARCIA A. WHEELER - BRANFORD CT, US
SHANNON D. SMITH - GUILFORD CT, US

International Classification:

G01N033/573

US Classification:

435/007400

Abstract:

Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide synthase in biological samples is also provided. Detection of inducible nitric oxide synthase is useful in the diagnosis of inflammatory responses such as infections mediated by bacteria, yeast or viruses, transplant rejection, rheumatoid arthritis, interstitial cystitis and cancer.