William F Degrado

US Patent:

6677431, Jan 13, 2004

Filed:

Dec 11, 2000

Appl. No.:

09/732911

Inventors:

William F. DeGrado - Media PA
Yoshimoto Hamuro - San Diego CA
Dahui Liu - Philadelphia PA

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 3804

US Classification:

530326, 514 13, 514 14, 514 15, 514 16, 514 17, 530327, 530328, 530329, 530332, 530345, 525 541

Abstract:

An antibacterial -peptide having the following formula: wherein R is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R is an amine-containing alkyl group having the formula â(CH ) NH , wherein m=1, 2, 3, 4, or 5, (CH ) NHC NHNH wherein x is 1, 2, 3, 4, or 5, a pyridyl, an alkylpryidyl, an amidine-substituted benzyl, a phenyl group, or a cyclic amidine; R is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; X is âNH , âOH, âNHR, or OR where R is alkyl, aryl or acyl groups either free or polymer-supported, a carboxamide, a substituted carboxamide, or a polymer; Y is H, an alkyl group, an acyl group, an acyl-terminated polymer, a sulphonamide, an ether, a urea, a urethane, or a polymer; and n is 2, 3, 4, 5, 6, or 7.

US Patent:

7173102, Feb 6, 2007

Filed:

Mar 7, 2002

Appl. No.:

10/471028

Inventors:

William F. DeGrado - Moylan PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US
Dahui Liu - Wynnewood PA, US
Jing Yuan - Lansdale PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C08G 18/00
C08G 63/00
C08G 69/02
C08G 71/02

US Classification:

528322, 528310, 528190, 528191, 528192, 528193, 528272, 528327, 428 59, 428123, 428357, 428409, 428543, 428152, 428153, 424 768, 424 7808, 424401, 424402, 424422, 424423, 424424, 424443, 427256

Abstract:

Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.

US Patent:

7590517, Sep 15, 2009

Filed:

May 28, 2003

Appl. No.:

10/446171

Inventors:

Robert Doerksen - Philadelphia PA, US
Bin Chen - Baton Rouge LA, US
William F. DeGrado - Media PA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G06G 7/48

US Classification:

703 11

Abstract:

Methods, systems, and computer program products for computational polymer processing including, without limitation, computational amphiphilic polymer design, conformational energy minimization, generation and refinement of torsional parameters for sub-units of potential polymers, generation of modified force field parameters, and prediction of conformational information for potential polymers. A target polymer backbone or portion thereof is identified. Small model compounds that have structural connectivities that are similar to structural connectivities of the target polymer backbone or portion thereof, are identified, whereby the combination of the small model compounds serve as a model of the target polymer or portion thereof. Gradient-corrected density functional theory (“DFT”) torsional potentials are calculated for the small model compounds, wherein energies are calculated at unconstrained and constrained geometries of the selected small model compounds. New torsional parameters are then obtained from the DFT torsional potentials.

US Patent:

7910609, Mar 22, 2011

Filed:

Sep 24, 2008

Appl. No.:

12/237015

Inventors:

William F. DeGrado - Media PA, US
Seth E. Snyder - Hackensack NJ, US
Meredith W. Miller - Philadelphia PA, US
Sandeep Basra - Munich, DE
Joel S. Bennett - Bryn Mawr PA, US
Sungwook Choi - San Diego CA, US

Assignee:

The Trustees Of The University Of Pennsylvania - Philadelphia PA

International Classification:

A01N 43/00
A61K 31/397
C07D 277/00
C07D 205/00

US Classification:

514327, 548200, 548953

Abstract:

Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.

US Patent:

8222456, Jul 17, 2012

Filed:

Jan 21, 2005

Appl. No.:

11/038787

Inventors:

William F. DeGrado - Moylan PA, US
Dahui Liu - Wynnewood PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C07C 211/27
C07C 279/06
C07C 233/77
A61K 31/135
A61K 31/155
A61K 31/16
A61K 31/132

US Classification:

564374, 564157, 564236, 564389, 514616, 514634, 514654, 514655

Abstract:

The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.

US Patent:

8236800, Aug 7, 2012

Filed:

Oct 31, 2007

Appl. No.:

11/980785

Inventors:

William F. DeGrado - Moylan PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US
Dahui Liu - Wynnewood PA, US
Jing Yuan - Lansdale PA, US
Sungwook Choi - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A01N 43/58
A01N 43/60
A01N 43/54
A61K 31/50
A61K 31/495
C07D 239/42
C07D 471/04
C07D 471/22
C07D 487/04

US Classification:

514247, 514248, 514256, 514257

Abstract:

The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

US Patent:

8258159, Sep 4, 2012

Filed:

Jun 7, 2006

Appl. No.:

11/916746

Inventors:

William F. DeGrado - Media PA, US
Joel S. Bennett - Bryn Mawr PA, US
Seth Elliott Snyder - Bronx NY, US
Sungwook Choi - San Diego CA, US

Assignee:

The Trustees Of The University Of Pennsylvania - Philadelphia PA

International Classification:

A01N 43/40
A01N 43/36
A61K 31/445
A61K 31/40

US Classification:

514327, 514423

Abstract:

Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.

US Patent:

8278309, Oct 2, 2012

Filed:

Oct 26, 2009

Appl. No.:

12/605584

Inventors:

William F. DeGrado - Media PA, US
Dahui Liu - Wynnewood PA, US
Richard W. Scott - Radnor PA, US
Yongjiang Xu - Wayne PA, US
Haizhong Tang - Lawrenceville NJ, US
Bozena Korczak - Wayne PA, US

Assignee:

PolyMedix, Inc. - Radnor PA

International Classification:

A01N 43/54
C07D 239/02

US Classification:

514256, 544335

Abstract:

The present invention provides arylamide compounds and methods of making and using them as antibiotics.