The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
Camellia W. Adams - San Jose CA, US Napoleone Ferrara - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Weiguang Mao - San Mateo CA, US Leonard G. Presta - San Francisco CA, US Max L. Tejada - Campbell CA, US
Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies.
Camellia Adams - San Jose CA, US Napoleone Ferrara - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Weiguang Mao - San Mateo CA, US Leonard Presta - San Francisco CA, US Max Tejada - Campbell CA, US
Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies.
Cysteine Engineered Anti-Tenb2 Antibodies And Antibody Drug Conjugates
Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I:
4241721, 536 2353, 4353201, 435325, 435 696, 514 44 R
Abstract:
The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
Weiguang Mao - San Mateo CA, US Paul Polakis - Mill Valley CA, US Andrew Polson - San Francisco CA, US Rajesh Vij - San Mateo CA, US Yan Wu - Foster City CA, US Wei-Ching Liang - Foster City CA, US
Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection, by Natalie Sauerwald, Zijun Zhang, Irene Ramos, Venugopalan D. Nair, Alessandra Soares-Schanoski, Yongchao Ge, Weiguang Mao, Hala Alshammary, Ana S. Gonzalez-Reiche, Adriana van de Guchte, Carl W. Gofor