Walter C Gogan

Address:

23 Roberts St, Winslow, ME 04901

Phone:

2078732302

VIN:

2G4WD552271113061

Make:

BUICK

Model:

LACROSSE

Year:

2007

US Patent:

20020051748, May 2, 2002

Filed:

Dec 22, 1998

Appl. No.:

09/226525

Inventors:

WILLIAM C. SNOW - WINSLOW ME, US
WALTER C. GOGAN - WINSLOW ME, US

International Classification:

A61K047/44
A61M036/14
A61K039/38
A61K045/00
A61K047/00
A61K051/00

US Classification:

424/001110, 424/204100, 424/205100, 424/278100, 424/283100, 424/001290, 424/001570, 424/001730

Abstract:

A water-in-oil-in-water (W/O/W) emulsion to be used in an antigen delivery system to induce rapid and long-lasting immunity among populations of livestock, birds, and fish. The external aqueous phase of the W/O/W emulsion contains a thixotropic inorganic salt, such as aluminum hydroxide or alum. The presence of the inorganic salt helps to elicit both a Th1 and a Th2 response from the subject's immune system, and the thixotropic properties of the salt stabilize the water-in-oil-in-water emulsion, thereby providing a longer vaccine shelf life. The antigen dose to be delivered to the subject may be contained in entirely in the internal aqueous phase. Alternatively, a first portion of the total antigen dose may be included in the internal aqueous phase and a second portion is included in the external aqueous phase. The incorporation of a portion of the antigen in the external aqueous phase triggers a more uniform immune response across a vaccinated population. The W/O/W based vaccines can be administered either by injection or orally.