Timothy A Bertram

Author:

Timothy Bertram

ISBN #:

0861886771

US Patent:

8318484, Nov 27, 2012

Filed:

Nov 12, 2009

Appl. No.:

12/617721

Inventors:

Sharon C. Presnell - Lewisville NC, US
Andrew Bruce - Lexington NC, US
Shay M. Wallace - Winston-Salem NC, US
Sumana Choudhury - Kernersville NC, US
Russell W. Kelley - Winston-Salem NC, US
Manuel J. Jayo - Winston-Salem NC, US
Jessica J. Reinsch - Charlotte NC, US
Patricia D. Tatsumi - Greensboro NC, US
Timothy A. Bertram - Winston-Salem NC, US
Eric S. Werdin - Lewisville NC, US
Oluwatoyin A. Knight - Winston-Salem NC, US
H. Scott Rapoport - Winston-Salem NC, US
Roger M. Ilagan - Burlington NC, US

Assignee:

Tengion, Inc. - Winston-Salem NC

International Classification:

C12N 5/00

US Classification:

435325, 424 937

Abstract:

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

US Patent:

8337485, Dec 25, 2012

Filed:

Nov 4, 2009

Appl. No.:

12/612606

Inventors:

John W. Ludlow - Carrboro NC, US
Manuel J. Jayo - Winston-Salem NC, US
Joydeep Basu - Winston-Salem NC, US
Timothy A. Bertram - Winston-Salem NC, US
Christopher W. Genheimer - Colfax NC, US
Kelly I. Guthrie - Winston-Salem NC, US
Roger M. Ilagan - Burlington NC, US
Deepak Jain - Winston-Salem NC, US
Oluwatoyin A. Knight - Winston-Salem NC, US
Richard Payne - Winston-Salem NC, US
Sarah F. Quinlan - Clemmons NC, US
H. Scott Rapoport - Winston-Salem NC, US
Namrata D. Sangha - Winston-Salem NC, US

Assignee:

Tengion, Inc. - Winston-Salem NC

International Classification:

A61M 27/00
A61F 2/04
B05D 5/00

US Classification:

604544, 623 2366, 427 225

Abstract:

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

US Patent:

20030224407, Dec 4, 2003

Filed:

Mar 6, 2003

Appl. No.:

10/383212

Inventors:

Timothy Bertram - Old Lyme CT, US
Michael Browne - Welwyn Garden City, GB
Peter Bugelski - Coventryville PA, US
Paul England - St. Albans, GB
Ian Mitchell - Dorchester, GB
David Morgan - Wayne PA, US
Andrew Rut - Sunset Place, SG

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

Methods are disclosed for assessing the toxic or pathologic effects of a selected environmental stimulus or reagent on a mammalian cell by determining on a DNA grid a “fingerprint” hybridization pattern. The fingerprint pattern is characteristic of chemically or structurally diverse stimuli or reagents, which having a common adverse effect on gene transcription. A test compound is screened for a similar toxic effect by comparing its hybridization pattern on a similar grid to the fingerprint.

US Patent:

20070275363, Nov 29, 2007

Filed:

Feb 12, 2007

Appl. No.:

11/706173

Inventors:

Timothy Bertram - Winston-Salem NC, US
Andrew Bruce - Lexington NC, US
Deepak Jain - Winston-Salem NC, US
John Ludlow - Carrboro NC, US
Darrell McCoy - Clemmon NC, US
Namrata Sangha - Winston-Salem NC, US

International Classification:

A01N 1/00
C12M 1/12

US Classification:

435001200, 435297300

Abstract:

Bioreactors are used in neo-organ production to allow for an appropriate environment for the maintenance of healthy culturing conditions from pre-wetting to shipment of the neo-organ. The closed system “all-in-one bioreactor” is designed to allow for minimal exposure of the scaffold to the open air in order to maintain sterility. The design allows for the same container to be utilized for sterilization, pre-wetting, cell seeding, medium exchange, and shipment. The “all-in-one” bioreactor also remains completely closed after the urothelial cell seeding step to the implantation at the clinical site. This allows for sufficient time for release testing to occur so the neo-organ can be implanted into the patient.

US Patent:

20070276507, Nov 29, 2007

Filed:

Feb 12, 2007

Appl. No.:

11/706081

Inventors:

Timothy Bertram - Winston-Salem NC, US
Andrew Bruce - Lexington NC, US
Deepak Jain - Winston-Salem NC, US
Manuel Jayo - Winston-Salem NC, US
John Ludlow - Carrboro NC, US
Darrell McCoy - Clemmon NC, US
Richard Payne - Winston-Salem NC, US
Namrata Sangha - Winston-Salem NC, US

International Classification:

A61F 2/02

US Classification:

623023650

Abstract:

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

US Patent:

20110123455, May 26, 2011

Filed:

Nov 12, 2010

Appl. No.:

12/945436

Inventors:

Sharon C. Presnell - Lewisville NC, US
Thomas Spencer - Winston-Salem NC, US
Belinda J. Wagner - Frederick MD, US
Manuel J. Jayo - Winston-Salem NC, US
Timothy Bertram - Winston-Salem NC, US
Roger M. Ilagan - Burlington NC, US
Russell W. Kelly - Burlington NC, US
H. Scott Rapoport - Sopelana, ES
Andrew Bruce - Lexington NC, US

International Classification:

A61K 49/00
C12Q 1/02

US Classification:

424 92, 435 29

Abstract:

The present invention concerns a non-biased, combinatorial approach to the identification of components that modulate a regenerative response in a target tissue, thereby restoring or partially restoring homeostasis to the target tissue. The methods of the present invention are based on in vivo testing, with or without prior in vitro predictive functional testing or combinatorial testing.

US Patent:

20110257726, Oct 20, 2011

Filed:

Mar 1, 2011

Appl. No.:

13/037559

Inventors:

Timothy A. Bertram - Winston-Salem NC, US
Andrew Bruce - Lexington NC, US
Deepak Jain - Winston-Salem NC, US
Manuel J. Jayo - Winston-Salem NC, US
John W. Ludlow - Carrboro NC, US
Darell McCoy - Clemmons NC, US
Richard Payne - Winston-Salem NC, US
Namrata D. Sangha - Winston-Salem NC, US

International Classification:

A61F 2/82
A61K 35/12
A61P 13/10
A61K 9/00

US Classification:

623 115, 424422, 424 937

Abstract:

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

US Patent:

20130149347, Jun 13, 2013

Filed:

Oct 26, 2012

Appl. No.:

13/661668

Inventors:

Andrew Bruce - Lexington NC, US
Shay M. Wallace - Winston-Salem NC, US
Sumana Choudhury - Kernersville NC, US
Russell W. Kelley - Winston-Salem NC, US
Manuel J. Jayo - Winston-Salem NC, US
Jessica J. Reinsch - Charlotte NC, US
Patricia D. Tatsumi - Greensboro NC, US
Timothy A. Bertram - Winston-Salem NC, US
Eric S. Werdin - Lewisville NC, US
Oluwatoyin A. Knight - Winston-Salem NC, US
H. Scott Rapoport - Winston-Salem NC, US
Roger M. ILAGAN - Burlington NC, US

Assignee:

TENGION, INC. - Winston-Salem NC

International Classification:

A61K 35/22
C12N 5/071

US Classification:

424400, 424 937, 435347

Abstract:

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.