Timothy W Behrens

US Patent:

7571055, Aug 4, 2009

Filed:

Oct 13, 2005

Appl. No.:

11/251589

Inventors:

Timothy W. Behrens - Minnetonka MN, US
Emily C. Gillespie - Savage MN, US
Peter K. Gregersen - Larchmont NY, US

Assignee:

Regents of the University of Minnesota - Sint Paul MN
The Feinstein Institute for Medical Research - Manhasset NY

International Classification:

G06F 19/00
C12Q 1/68

US Classification:

702 19, 435 6

Abstract:

This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment effectiveness are provided herein.

US Patent:

7910299, Mar 22, 2011

Filed:

Oct 3, 2006

Appl. No.:

11/538348

Inventors:

Timothy W. Behrens - Minnetonka MN, US
Emily C. Baechler - Minneapolis MN, US
Peter K. Gregersen - Larchmont NY, US

Assignee:

Regents of the University of Minnesota - Saint Paul MN
The Feinstein Institute for Medical Research - Manhasset NY

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 235, 536 2431

Abstract:

The invention relates to methods and materials involved in diagnosing SLE. More particularly, the invention relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, the invention provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls.

US Patent:

8148074, Apr 3, 2012

Filed:

Sep 23, 2009

Appl. No.:

12/565480

Inventors:

Timothy W. Behrens - Burlingame CA, US
Robert R. Graham - San Francisco CA, US
David Altshuler - Brookline MA, US

Assignee:

Regents of the University of Minnesota - Saint Paul MN
General Hospital Corporation - Boston MA

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 611, 536 235

Abstract:

Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.

US Patent:

20040033498, Feb 19, 2004

Filed:

Aug 16, 2002

Appl. No.:

10/222202

Inventors:

Timothy Behrens - Minnetonka MN, US
Emily Baechler - Minneapolis MN, US
Peter Gregersen - Larchmont NY, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

The invention relates to methods and materials involved in diagnosing SLE. More particularly, the invention relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, the invention provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls.

US Patent:

20070141627, Jun 21, 2007

Filed:

Oct 18, 2006

Appl. No.:

11/550673

Inventors:

Timothy Behrens - Burlingame CA, US
Emily Gillespie - Savage MN, US
Peter Gregersen - Larchmont NY, US
Jason Bauer - St. Paul MN, US

International Classification:

G01N 33/53

US Classification:

435007100

Abstract:

This document relates to methods and materials involved in diagnosing SLE. For example, this document provides arrays for detecting polypeptides that can be used to diagnose SLE in a mammal. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment effectiveness are provided herein.

US Patent:

20080026386, Jan 31, 2008

Filed:

Mar 30, 2007

Appl. No.:

11/694272

Inventors:

Timothy Behrens - Burlingame CA, US
Robert Graham - San Francisco CA, US
David Altshuler - Brookline MA, US

International Classification:

C12Q 1/68
C12Q 1/02

US Classification:

435006000, 435029000

Abstract:

Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.

US Patent:

20090004189, Jan 1, 2009

Filed:

Jun 13, 2008

Appl. No.:

12/138696

Inventors:

TIMOTHY W. BEHRENS - Burlingame CA, US
Michael J. Townsend - San Jose CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39/395
A61P 19/02
G01N 33/68

US Classification:

4241331, 4241391, 436 86

Abstract:

Methods and assays examining expression of one or more biomarkers in a sample are provided for predicting or indicating the effectiveness of treatment of a rheumatoid arthritis patient with a B-cell antagonist. Methods are provided for identifying patients whose rheumatoid arthritis is likely to be responsive to B-cell-antagonist, anti-rheumatoid arthritis therapy. Methods for treating such patients with B-cell antagonists that incorporate the above methodology are also provided. Further provided are kits and articles of manufacture useful for such methods.

US Patent:

20090204489, Aug 13, 2009

Filed:

Apr 1, 2008

Appl. No.:

12/060572

Inventors:

TIMOTHY BEHRENS - BURLINGAME CA, US
THARAKNATH RAO - BASEL, CH

Assignee:

GENENTECH, INC. - SOUTH SAN FRANCISCO CA

International Classification:

G06Q 30/00
A61K 39/395
A61K 38/16
A61K 39/44
A61K 31/519
A61K 31/56
C12Q 1/68
G06N 5/00

US Classification:

705 14, 4241301, 514 12, 4241331, 4241781, 5142621, 514171, 435 6, 706 45

Abstract:

Methods and assays examining expression of one or more biomarkers in a sample are provided for predicting or indicating the effectiveness of treatment of a rheumatoid arthritis (RA) patient with a B-cell antagonist. Methods are provided for identifying patients whose RA is likely to be responsive to anti-RA therapy using a B-cell-antagonist. Methods for treating such patients with B-cell antagonists that incorporate the above methodology are also provided. Further provided are kits and articles of manufacture useful for such methods.