Thomas Albert Engler - Indianapolis IN, US Kelly Wayne Furness - Avon IN, US Sushant Malhotra - Indianapolis IN, US Stephen Lyle Briggs - Indianapolis IN, US Harold Burns Brooks - Carmel IN, US David K yes Clawson - Indianapolis IN, US Concepcion Sanchez-Martinez - Madrid, ES Faming Zhang - Carmel IN, US Guoxin Zhu - Noblesville IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/40 C07D 481/00
US Classification:
514410, 548416, 548417
Abstract:
The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
Douglas Wade Beight - Frankfort IN, US Timothy Paul Burkholder - Carmel IN, US Todd Vincent Decollo - Noblesville IN, US Alexander Glenn Godfrey - Mooresville IN, US Charles Raymond Heap - West Sand Lake NY, US Chi-Hsin Richard King - Slingerlands NY, US Hong-Yu Li - Zionsville IN, US William Thomas McMillen - McCordsville IN, US Jason Scott Sawyer - Indianapolis IN, US Yan Wang - Carmel IN, US Clive Gideon Diefenbacher - Greenwood IN, US Thomas Albert Engler - Indianapolis IN, US Sushant Malhotra - Indianapolis IN, US Sreenivasa Reedy Mundla - Westfield IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D 241/36 C07D 217/00 C07D 401/00
US Classification:
544353, 546139, 5462757
Abstract:
The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
Pyrrole-2, 5Dione Derivatives And Their Used As Gsk-3 Inhibitors
Pamela Ann Albaugh - Carlsbad CA, US Jochen Ammenn - Hamburg, DE Timothy Paul Burkholder - Carmel IN, US Joshua Ryan Clayton - Cicero IN, US Scott Eugene Conner - Indianapolis IN, US Brian Eugene Cunningham - Martinsville IN, US Thomas Albert Engler - Indianapolis IN, US Kelly Wayne Furness - Avon IN, US James Robert Henry - Indianapolis IN, US Sushant Malhotra - Indianapolis IN, US Mark Joseph Tebbe - Indianapolis IN, US Guoxin Zhu - Noblesville IN, US YiHong Li - Carmel IN, US Brian Raymond Berridge - Greenfield IN, US Charles Edward Ruegg - Indianapolis IN, US John Morris Sullivan - Greenfield IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D 209/12 C07D 207/24 C07D 211/06
US Classification:
548469, 548547, 546184
Abstract:
The present invention provides kinase inhibitors of Formula (I).
Clive Gideon Diefenbacher - Greenwood IN, US Thomas Albert Engler - Indianapolis IN, US Hong-Yu Li - Zionsville IN, US Sushant Malhotra - Los Altos CA, US Jason Scott Sawyer - Indianapolis IN, US Yan Wang - Carmel IN, US
Thomas Albert Engler - Indianapolis IN, US James Robert Henry - Indianapolis IN, US Sushant Malhotra - Burlingame CA, US Jon Kevin Reel - Carmel IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61P 25/28 A61K 31/55 C07D 487/06
US Classification:
514220, 540561
Abstract:
The present invention provides kinase inhibitors of Formula I.
Thomas Albert Engler - Indianapolis IN, US Timothy Paul Burkholder - Carmel IN, US Joshua Ryan Clayton - Cicero IN, US Clive Gideon Diefenbacher - Greenwood IN, US Kelly Wayne Furness - Avon IN, US James Robert Henry - Indianapolis IN, US Yihong Li - Carmel IN, US Sushant Malhotra - Indianapolis IN, US Angela Lynn Marquart - Greenwood IN, US Johnathan Alexander McLean - Indianapolis IN, US David Mendel - Indianapolis IN, US Jon Kevin Reel - Carmel IN, US Brian Raymond Berridge - Greenfield IN, US Charles Edward Ruegg - Indianapolis IN, US John Morris Sullivan - Greenfield IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61P 25/08 A61K 31/55 C07D 487/06
US Classification:
540220, 540561
Abstract:
The present invention provides kinase inhibitors of Formula I.
Potentiation Of Cancer Chemotherapy By 7-(2, 5-Dihydro-4-Imidazo [1, 2-A] Pyridine-3-Yl-2,5-Dioxo-1H-Pyrrol-3-Yl)-9-Fluoro-1,2,3,4 Tetrahydro-2-(1-Piperidinyl-Carbonyl)-Pyrrolo [3,2,1-Jk] [1,4] Benzodiazepine
Marcio Chedid - Fishers IN, US Thomas Albert Engler - Indianapolis IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A01N 43/00 A01N 43/62 A61K 31/33 A61K 31/55
US Classification:
514183, 514220
Abstract:
A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine, useful for the method and a process for preparing said compositions.