Thomas A Engler

age ~70

from Indianapolis, IN

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Thomas Engler Phones & Addresses

Methods And Compounds For Treating Proliferative Diseases
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US Patent:

7109229, Sep 19, 2006
Filed:

Sep 24, 2001
Appl. No.:

10/344245
Inventors:

Thomas Albert Engler - Indianapolis IN, US
Kelly Wayne Furness - Avon IN, US
Sushant Malhotra - Indianapolis IN, US
Stephen Lyle Briggs - Indianapolis IN, US
Harold Burns Brooks - Carmel IN, US
David K yes Clawson - Indianapolis IN, US
Concepcion Sanchez-Martinez - Madrid, ES
Faming Zhang - Carmel IN, US
Guoxin Zhu - Noblesville IN, US
Assignee:

Eli Lilly and Company - Indianapolis IN
International Classification:

A61K 31/40
C07D 481/00
US Classification:

514410, 548416, 548417
Abstract:

The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).

Compounds As Pharmaceutical Agents
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US Patent:

7405299, Jul 29, 2008
Filed:

Nov 24, 2003
Appl. No.:

10/535381
Inventors:

Douglas Wade Beight - Frankfort IN, US
Timothy Paul Burkholder - Carmel IN, US
Todd Vincent Decollo - Noblesville IN, US
Alexander Glenn Godfrey - Mooresville IN, US
Charles Raymond Heap - West Sand Lake NY, US
Chi-Hsin Richard King - Slingerlands NY, US
Hong-Yu Li - Zionsville IN, US
William Thomas McMillen - McCordsville IN, US
Jason Scott Sawyer - Indianapolis IN, US
Yan Wang - Carmel IN, US
Clive Gideon Diefenbacher - Greenwood IN, US
Thomas Albert Engler - Indianapolis IN, US
Sushant Malhotra - Indianapolis IN, US
Sreenivasa Reedy Mundla - Westfield IN, US
Assignee:

Eli Lilly and Company - Indianapolis IN
International Classification:

C07D 241/36
C07D 217/00
C07D 401/00
US Classification:

544353, 546139, 5462757
Abstract:

The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.

Tgf-Β Inhibitors
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US Patent:

7511056, Mar 31, 2009
Filed:

Nov 2, 2005
Appl. No.:

11/577094
Inventors:

Clive Gideon Diefenbacher - Greenwood IN, US
Thomas Albert Engler - Indianapolis IN, US
Hong-Yu Li - Zionsville IN, US
Sushant Malhotra - Los Altos CA, US
Jason Scott Sawyer - Indianapolis IN, US
Yan Wang - Carmel IN, US
Assignee:

Eli Lilly and Company - Indianapolis IN
International Classification:

A01N 43/42
A61K 31/44
C07D 491/02
C07D 498/02
C07D 401/00
US Classification:

514300, 514338, 546121, 5462767
Abstract:

The present invention is directed to inhibitors of TGF-β of Formula I:.

Potentiation Of Cancer Chemotherapy By 7-(2, 5-Dihydro-4-Imidazo [1, 2-A] Pyridine-3-Yl-2,5-Dioxo-1H-Pyrrol-3-Yl)-9-Fluoro-1,2,3,4 Tetrahydro-2-(1-Piperidinyl-Carbonyl)-Pyrrolo [3,2,1-Jk] [1,4] Benzodiazepine
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US Patent:

8318713, Nov 27, 2012
Filed:

Jun 20, 2008
Appl. No.:

12/664664
Inventors:

Marcio Chedid - Fishers IN, US
Thomas Albert Engler - Indianapolis IN, US
Assignee:

Eli Lilly and Company - Indianapolis IN
International Classification:

A01N 43/00
A01N 43/62
A61K 31/33
A61K 31/55
US Classification:

514183, 514220
Abstract:

A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine, useful for the method and a process for preparing said compositions.