Metal colloidal aggregates substrates useful for metal enhanced fluorescence applications, are disclosed. Method of making and using these colloidal aggregates for enhancing the fluorescent signal in biological assays are also described.
The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods.
- Lincoln NE, US Rose Skopp - Lincoln NE, US Vassil Elitzin - Lincoln NE, US Nisha Padhye - Lincoln NE, US Teresa Urlacher - Lincoln NE, US
Assignee:
LI-COR, Inc. - Lincoln NE
International Classification:
C09B 23/01 G01N 33/58
Abstract:
The present disclosure embodies compounds, methods, and kits that are useful in connection with the detection of analytes of all types (e.g., biological molecules such as proteins, organic molecules, natural or synthetic molecules). The disclosure is particularly applicable to detection of proteins and nucleic acids using all types of membrane-based assays by techniques such as Western blotting, Dot blotting, Southern blotting, and Northern blotting.
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