Syed Anwar Hashsham

US Patent:

20100105035, Apr 29, 2010

Filed:

Nov 21, 2007

Appl. No.:

12/312686

Inventors:

Syed Anwar Hashsham - Okemos MI, US
James M. Tiedje - Lansing MI, US
Erdogan Gulari - Ann Arbor MI, US
Dieter Tourlousse - East Lansing MI, US
Robert Stedtfeld - Lansing MI, US
Farhan Ahmad - East Lansing MI, US
Gregoire Seyrig - Lansing MI, US
Onnop Srivannavit - Ann Arbor MI, US

International Classification:

C12Q 1/68
G01J 1/58
C40B 60/12
C12M 1/34
C12M 1/40
C12Q 1/04
C12P 19/34

US Classification:

435 6, 2504581, 506 39, 4352887, 2504591, 435 34, 435 912

Abstract:

The present invention provides compositions providing and methods using fluorescence detection device, comprising an electroluminescent light (EL) source, for measuring fluorescence in biological samples. In particularly preferred embodiments, the present invention provides an economical, battery powered and Hand-held device for detecting fluorescent light emitted from reporter molecules incorporated into DNA, RNA, proteins or other biological samples, such as a fluorescence emitting biological sample on a microarray chip. Further, a real-time hand-held PCR Analyzer device comprising an EL light source for measuring fluorescence emissions from amplified DNA is provided.

US Patent:

20140211204, Jul 31, 2014

Filed:

Aug 30, 2013

Appl. No.:

14/015787

Inventors:

- EAST LANSING MI, US
SYED HASHSHAM - OKEMOS MI, US
JAMES TIEDJE - LANSING MI, US
ERDOGAN GULARI - ANN ARBOR MI, US
FARHAN AHMAD - SEATTLE WA, US
GREGOIRE SEYRIG - PASADENA CA, US
DIETER TOURLOUSSE - TOKYO, JP
MAGGIE KRONLEIN - LANSING MI, US
YEN-CHENG TERRY LIU - EAST LANSING MI, US

Assignee:

BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY - EAST LANSING MI

International Classification:

G01N 21/01
G01N 21/64

US Classification:

356244, 2504581, 250206

Abstract:

The present invention provides compositions for making and methods of using a hand-held nucleic acid amplification device, comprising a disposable biochip with a series of sample wells, each sample well having a novel optical arrangement that includes a light-emitting diode (LED) and a single light capturing element (e.g. a photodiode) for quickly measuring light emissions from biological samples such as nucleic acid amplification reactions. Such a device can utilize isothermal amplification for obtaining detectable yields of amplified nucleic acid product in short time periods, for example, within seconds.