Samuel J. Danishefsky - Englewood NJ, US Don M. Coltart - New York NY, US Stacy J. Keding - New York NY, US Kaustav Biswas - Thousand Oaks CA, US Philip O. Livingston - New York NY, US Jennifer R. Allen - Indianapolis IN, US Lawrence Williams - Edison NJ, US
Assignee:
Sloan-Kettering Institute For Cancer Research - New York NY
The present invention provides novel glycosides and glycoconjugates, glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive glycopeptides as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier.
1, 5-Diphenyl-3-Benzylamino-1, 5-Dihydropyrrolidin-2-One As Cb1 Receptor Modulators
David Scott Coffey - Fishers IN, US Jingdan Hu - Carmel IN, US Stacy Jo Keding - Zionsville IN, US John Mehnert Schaus - Zionsville IN, US David Edward Tupper - Basingstoke, GB
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/4439 C07D 401/12
US Classification:
514343, 5462784
Abstract:
Compounds and pharmaceutical compositions comprising compounds of the Formula.
Clustered Multi-Antigenic Carbohydrate Constructs, Methods For Their Preparation, And Uses Thereof
Samuel Danishefsky - Englewood NJ, US Stacy Keding - New York NY, US
International Classification:
A61K039/00 C07K014/47
US Classification:
424/185100, 530/404000
Abstract:
The present invention provides novel clustered multi-antigenic constructs having the structure: and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive constructs as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier.
- Indianapolis IN, US Erik James Hembre - Indianapolis IN, US Nicholas Allan Honigschmidt - Lakeville MN, US Maria Angeles Martinez-Grau - Madrid, ES Gema Ruano Plaza - Madrid, ES Almudena Rubio - Carmel IN, US Stacy Jo Keding - Brownsburg IN, US Daryl Lynn Smith - Fishers IN, US
International Classification:
C07D 239/42 C07D 401/12 C07D 417/14
Abstract:
The present invention provides novel GOAT inhibitors and their salts and pharmaceutical compositions thereof.