Srinivas Kothakota

US Patent:

8324165, Dec 4, 2012

Filed:

May 13, 2009

Appl. No.:

12/992582

Inventors:

Kalyani Penta - Palo Alto CA, US
Srinivas Kothakota - Pacifica CA, US
Lewis T. Williams - Mill Valley CA, US
Kevin Hestir - Kensington CA, US
Shannon Marshall - Baltimore MD, US
Jeffrey Finer - Foster City CA, US
Yan Wang - Redwood City CA, US

Assignee:

Five Prime Therapeutics, Inc. - South San Francisco CA

International Classification:

A61P 19/02
A61K 38/17

US Classification:

514 168, 514825, 530350

Abstract:

The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.

US Patent:

20020076761, Jun 20, 2002

Filed:

Aug 22, 2001

Appl. No.:

09/935390

Inventors:

Jaime Escobedo - Alamo CA, US
Pablo Garcia - San Francisco CA, US
Qianjin Hu - Castro Valley CA, US
Srinivas Kothakota - Santa Monica CA, US
Lewis Williams - Mill Valley CA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/00
C12P021/02
C12N005/06
C07K014/435

US Classification:

435/069100, 435/183000, 435/320100, 435/325000, 435/006000, 530/350000, 536/023500

Abstract:

Secreted proteins can be identified using a method which exploits the ability of microsomes to modify proteins post-translationally. Nineteen human secreted proteins and full-length cDNA sequences encoding the proteins have been identified using this method. The proteins and cDNA sequences can be used, inter alia, for targeting other proteins to the membrane or extracellular milieu.

US Patent:

20050003558, Jan 6, 2005

Filed:

Apr 29, 2004

Appl. No.:

10/837288

Inventors:

Ronald Zuckermann - El Cerrito CA, US
Eric Beausoleil - San Francisco CA, US
Matthew Wachowicz - San Francisco CA, US
Srinivas Kothakota - Santa Monica CA, US

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

G01N033/543

US Classification:

436518000

Abstract:

Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compatible with biological samples, for example, a cell line, a biological fluid such as blood, or a tissue cell lysate. The ligands may include affinity property groups and hydrophilic groups pendent from a backbone, and be configured to at least partially resolve components of a biological sample. Affinity supports in accordance with the present invention may be used in a variety of techniques and apparatuses to achieve improved separations of complex biological samples and thereby enhance the results of biological sample component fractionations, enrichments, purifications, expression product determinations and comparisons, and other biological sample processing techniques. In addition, the affinity supports may be included in kits useful in processing biological samples.

US Patent:

20070054852, Mar 8, 2007

Filed:

May 30, 2006

Appl. No.:

11/442294

Inventors:

Junyu Lin - Palo Alto CA, US
Ge Wu - La Canada CA, US
Srinivas Kothakota - Pacifica CA, US
Lorianne Masuoka - Oakland CA, US

International Classification:

A61K 38/17
C12Q 1/68

US Classification:

514012000, 435006000

Abstract:

The present invention relates to therapeutic uses of Semaphorin 3F or related proteins. The therapeutic uses include methods of using Semaphorin 3F compounds alone, or in conjunction with other agents, for the stimulation of neuromuscular regeneration, and the treatment of diseases or conditions characterized by muscle denervation and muscle atrophy.

US Patent:

20080112937, May 15, 2008

Filed:

Jul 19, 2005

Appl. No.:

11/632860

Inventors:

Lewis T Williams - San Francisco CA, US
Hongbing Zhang - San Francisco CA, US
Srinivas Kothakota - San Francisco CA, US
Kristen Pierce - San Francisco CA, US
Pierre Alvaro Beaurang - San Francisco CA, US
Keting Chu - Hills Borough CA, US

International Classification:

A61K 48/00
C12N 5/08
C12N 15/09

US Classification:

424 9321, 435455, 435325, 435366, 435368, 435372

Abstract:

Aspects of the present invention relate to compositions and methods of reprogramming a somatic cell to give rise to an autologous embryonic stem cell. These methods involve providing a somatic cell of a donor subject, introducing the somatic cell into an embryo of a recipient subject to produce a chimeric embryo, allowing the chimeric embryo to develop further wherein the somatic cell will reprogram, and then selecting an autologous embryonic stem cell that has developed from the somatic cell. The methods and composition of producing pluripotent embryonic stem cells from a donor's own somatic cells invite the possibility of a number of therapeutic applications, including organ transplant and treatment of autoimmune diseases, cancer, and degenerative disorders such as diabetes, Alzheimer's, and Parkinson's.

US Patent:

20110319324, Dec 29, 2011

Filed:

Nov 29, 2010

Appl. No.:

12/955779

Inventors:

Junyu Lin - Palo Alto CA, US
Srinivas Kothakota - Pacifica CA, US
Ge Wu - La Canada CA, US
Stephen Doberstein - San Francisco CA, US
Thomas Brennan - San Jose CA, US
Lorianne Masuoka - Oakland CA, US
Minmin Qin - Pleasanton CA, US
Shannon Marshall - Baltimore MD, US
Yan Wang - Redwood City CA, US
Diane Hollenbaugh - Mountain View CA, US
Lewis T. Williams - Mill Valley CA, US

International Classification:

A61K 38/18
A61P 3/10
A61K 38/28

US Classification:

514 65, 514 68

Abstract:

The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity.

US Patent:

6783929, Aug 31, 2004

Filed:

Nov 1, 2000

Appl. No.:

09/704422

Inventors:

Ronald N. Zuckermann - El Cerrito CA
Eric Beausoleil - San Francisco CA
Matthew Wachowicz - San Francisco CA
Srinivas Kothakota - Santa Monica CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

G01N 3353

US Classification:

435 4, 435 71, 435 79, 435 792, 435814, 436164, 436177, 436518, 436524, 436528, 210600, 210634, 210644, 210645, 210649, 210650, 210651, 210656

Abstract:

Provided are affinity support materials having intermediate binding affinity for biological samples. Among the materials provided by the present invention are hydrophilic solid supports composed of hydrophilic ligands coupled to hydrophilic matrixes which are compatible with biological samples, for example, a cell line, a biological fluid such as blood, or a tissue cell lysate. The ligands may include affinity property groups and hydrophilic groups pendent from a backbone, and be configured to at least partially resolve components of a biological sample. Affinity supports in accordance with the present invention may be used in a variety of techniques and apparatuses to achieve improved separations of complex biological samples and thereby enhance the results of biological sample component fractionations, enrichments, purifications, expression product determinations and comparisons, and other biological sample processing techniques. In addition, the affinity supports may be included in kits useful in processing biological samples.