Dana-Farber Cancer Institute
Beth Israel Deaconess Medical Center
Institute of Molecular Biology (Imb)
Senior Research Scientist
Lomonosov Moscow State University
Pirogov Russian National Research Medical University
Protein Chemistry Analytical Skills Sds Page Purification Biotechnology R&D Biochemistry Protein Purification Lifesciences Drug Discovery Molecular Biology Monoclonal Antibodies Cell Protein Expression Immunochemistry Science Cancer Chromatography Process Simulation Antibodies Elisa Biopharmaceuticals Cell Culture Cmc Regulatory Affairs Life Sciences
- La Jolla CA, US Ting XU - Needham MA, US Sergei BARBASHOV - Irvine CA, US Alexey REPIK - Moscow, RU Mikhail SAMSONOV - Moscow, RU Vasily IGNATIEV - Moscow, RU Shorena ARCHUADZE - Mowcow, RU
R-PHARM OVERSEAS, INC. - La Jolla CA
C07K 16/28 A61P 35/00
Fully human anti-PD-L1 antibodies and their corresponding applications. Fully human antibodies capable of specifically binding to human PD-L1 were obtained by employing a yeast display library-based screening technique and also by affinity maturation to further improve their affinity for PD-L1. The fully human anti-PD-L1 antibodies show good specificity, affinity and stability. They are capable of enhancing T cell activity by binding to activated T cells, while significantly inhibiting tumor growth, and can be used in the diagnosis and treatment of PD-L1-related cancers and other associated diseases.
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