- Maple Grove MN, US GENE T. STORBECK - Franklin MA, US SHANNON SMITH KENWOOD - Hopkinton MA, US CHRISTOPHER A. BENNING - Hopkinton MA, US SEAN CURRAN - Bourne MA, US SARAH JEAN HEIGHTON - Clinton MA, US
A cell filtration assembly adapted to capture cells from a biological sample during centrifugation includes a filter support member including a sample well and a filter membrane that spans the sample well. In some cases, the filter support member and/or the filter membrane may be adapted to be sectioned. In some cases, a protective element may be disposed over at least a portion of the filter support member in order to protect the filter support member from tissue processing reagents during processing of the cells captured from the biological sample.
Susan E. LACY - Westborough MA, US Lorenzo BENATUIL - Northborough MA, US Meha CHHAYA - Shrewsbury MA, US Emma FUNG - Northborough MA, US Renee MILLER - N. Grosvenordale CT, US Ravi CHARI - Norwich CT, US Sarah J. HEIGHTON - Leominster MA, US Jacqueline G. BIXBY - Auburn MA, US
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.