Lynn D. Hawkins - Concord MA Sally T. Ishizaka - Weston MA Jeffrey Rose - Chelmsford MA Hu Yang - North Andover MA
Assignee:
Eisai Company, Limited - Tokyo
International Classification:
C07F 909
US Classification:
558159, 4241841, 4242781
Abstract:
The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.
Immunological Adjuvant Compounds Compositions And Methods Of Use Thereof
Lynn D. Hawkins - Concord MA Sally T. Ishizaka - Weston MA Michael Lewis - Andover MA Pamela McGuiness - Methuen MA Jeffrey Rose - Chelmsford MA
Assignee:
Eisai Co., Ltd. - Tokyo
International Classification:
A61K 4500
US Classification:
4242781, 558166, 558172
Abstract:
The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
Immunomodulatory Compounds And Methods Of Use Thereof
Lynn D. Hawkins - Concord MA Sally T. Ishizaka - Weston MA Michael Lewis - Andover MA Pamela McGuinness - Methuen MA Jeffrey Rose - Chelmsford MA
Assignee:
Eisai Co., Ltd. - Tokyo
International Classification:
A61K 3166
US Classification:
514120, 4242781, 558169, 558166, 558172
Abstract:
The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
Immunomodulatory Compounds And Methods Of Use Thereof
Lynn D. Hawkins - Concord MA, US Sally T. Ishizaka - Weston MA, US Michael Lewis - Andover MA, US Pamela McGuinness - Methuen MA, US Jeffrey Rose - Chelmsford MA, US
Assignee:
Eisai R&D Management Co., Ltd. - Bunkyo-Ku, Tokyo
International Classification:
C07F 9/02
US Classification:
558166, 558169, 558170
Abstract:
The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
Immunomodulatory Compounds And Methods Of Use Thereof
Lynn D. Hawkins - Concord MA, US Sally T. Ishizaka - Weston MA, US
Assignee:
Eisai R&D Management Co., Ltd. - Tokyo
International Classification:
A61K 31/6615 C07F 9/10 C07F 9/113
US Classification:
514103, 514104, 562 12, 562 14, 562 20
Abstract:
The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.
Immunomodulatory Compounds And Methods Of Use Thereof
The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, therapeutic and prophylactic treatment of cancer, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.
Daniel P. Rossignol - Ridgefield Park NJ, US Sally T. Ishizaka - Weston MA, US Lynn D. Hawkins - Concord MA, US Scott Z. Fields - Towaco NJ, US
Assignee:
Eisai R&D Management Co., Ltd. - Tokyo
International Classification:
A61K 31/395
US Classification:
4242771, 4241781, 5142633, 514183, 514269
Abstract:
The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
The present invention provides benzoxazole compounds and pharmaceutically acceptable salts thereof and pharmaceutical compositions including the same. The present invention further provides methods of use as described herein.