Sabrina M Ronen from 42 Heather Ln, Orinda, CA 94563, age 65, Phone: 9253860312

Non-Invasive Molecular Imaging Of Cellular Histone Deacetylase Substrate Using Magnetic Resonance Spectroscopy (Mrs) Or Positron Emission Tomography (Pet)
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US Patent:

20100278730, Nov 4, 2010
Filed:

Apr 8, 2008
Appl. No.:

12/595281
Inventors:

Sabrina Ronen - Orinda CA, US
Juri Gelovani - Pearland TX, US
William Tong - Houston TX, US
Mian Alauddin - Houston TX, US
Uday Mukhopadhyay - Houston TX, US
Ashutosh Pal - Houston TX, US
International Classification:

A61K 51/00
A61B 5/055
C07C 237/28
US Classification:

424 165, 424 93, 564155
Abstract:

We disclose methods of detecting histone deacetylase activity in a mammal by administering to the mammal a compound comprising at least one atom having a nucleus detectable by magnetic resonance spectroscopy, wherein the compound is a substrate of histone deacetylase; and observing the compound or a cleavage product thereof in at least a portion of the body of the mammal by magnetic resonance spectroscopy (MRS). We also disclose methods of detecting histone deacetylase activity in a mammal by administering to the mammal a compound comprising at least one positron-emission-decaying radioisotope, wherein the compound is a substrate of histone deacetylase; and observing the compound or a cleavage product thereof in at least a portion of the body of the mammal by positron emission tomography (PET). We also disclose compounds useful as histone deacetylase substrates.

Detection Of Histone Deacetylase Inhibition
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US Patent:

20110312007, Dec 22, 2011
Filed:

Aug 1, 2011
Appl. No.:

13/195640
Inventors:

Sabrina M. Ronen - Bellaire TX, US
Juri G. Gelovani - Missouri City TX, US
William G. Bornmann - Missouri City TX, US
Jihai Pang - Pearland TX, US
Ashutosh Pal - Houston TX, US
William P. Tong - Houston TX, US
David S. Maxwell - Pearland TX, US
International Classification:

C12Q 1/34
C07F 7/22
C07C 235/78
C07C 271/22
C07C 259/06
US Classification:

435 18, 560159, 562623, 560 43, 556 87
Abstract:

Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I):One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (I) to a plurality of cells and monitoring the cells with magnetic resonance spectroscopy.

Detection Of Histone Deacetylase Inhibition
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US Patent:

20100062465, Mar 11, 2010
Filed:

Apr 20, 2007
Appl. No.:

12/297832
Inventors:

Sabrina M. Ronen - Bellaire TX, US
Juri G. Gelovani - Missouri City TX, US
William G. Bornmann - Missouri City TX, US
Jihai Pang - Pearland TX, US
Ashutosh Pal - Houston TX, US
William P. Tong - Houston TX, US
Ashutosh Paz - Houston TX, US
David S. Maxwell - Pearland TX, US
International Classification:

C12Q 1/34
C07C 271/10
C07F 7/22
C07C 233/01
US Classification:

435 18, 560159, 556 87, 564158
Abstract:

Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (1) to a plurality of cells and monitoring the cells with magnetic resonance spectroscopy.

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Location:

42 Heather Ln, Orinda, CA 94563

Industry:

Research

Work:

UCSF - UCSF since 2007
Professor in Residence

Interests:

Cooking
Electronics
Home Improvement
Gourmet Cooking
Sports
Home Decoration

Languages:

English

Sabrina M Ronen