Ruth Mcadam

US Patent:

58517618, Dec 22, 1998

Filed:

Dec 1, 1993

Appl. No.:

8/160524

Inventors:

Ruth Anne McAdam - Bronx NY
Jeremy Watson Dale - Guildford, GB
Zainul Fadziruddin Bin Zainuddin - Penang, MY
David Catty - Birmingham, GB2

Assignee:

Cogent Limited

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

The invention provides nucleotide probes, kits and methods for the detection and differentiation of Mycobacteria. The gene probes, kits and methods are useful for the diagnosis of tuberculosis and/or for epidemiological study tools for investigating the progress of infections caused by Mycobacteria. The gene probes as provided comprise part or all of nucleotide sequences provided in the soecification or an allele or a derivative of the nucleotide sequences. The gene probes can distinguish between M. tuberculosis, M. bovis and BCG as well as being able to distinguish between different strains of M. tuberculosis. The probes do not show significant hybridisation to nucleic acids from M. paratuberculosis, M. intracellulare, M.