Robert L. Fahrner - San Mateo CA, US Amy Laverdiere - San Francisco CA, US Paul J. McDonald - San Francisco CA, US Rhona M. O'Leary - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/00
US Classification:
530413, 530412, 5303871
Abstract:
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
Reducing Protein A Leaching During Protein A Affinity Chromatography
Robert L. Fahrner - San Mateo CA, US Amy Laverdiere - San Francisco CA, US Paul J. McDonald - San Francisco CA, US Rhona M. O'Leary - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/00
US Classification:
530413, 530412, 5303871
Abstract:
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.
Stabilizing Polypeptides Which Have Been Exposed To Urea
Jefferson C. Emery - San Mateo CA, US Paul J. McDonald - San Francisco CA, US Rhona O'Leary - San Francisco CA, US
International Classification:
C07K 1/18
US Classification:
5303891
Abstract:
A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.
Stabilizing Polypeptides Which Have Been Exposed To Urea
Genentech since 2011
Senior Director, gRED Business Operations and Project Team Leader Group Leader
Genentech Sep 2008 - May 2011
Director, Project Team Leader
Genentech Apr 2004 - Sep 2008
Director, Early Stage Purification
Genentech Jan 1998 - Mar 2004
Scientist/Senior Scientist, Purification Sciences
Genentech - South San Francisco Apr 1995 - Dec 1997
Post-Doc
Education:
Dublin City University 1986 - 1994
Bachelor of Science (BSc), Ph.D, Biotechnology, Biochemistry
Skills:
Biopharmaceuticals Pharmaceutical Industry Immunology Life Sciences Biotechnology Technology Transfer Molecular Biology Monoclonal Antibodies Team Leadership Strategic Leadership Executive Communications Lifesciences Fda Validation Biochemistry Strategic Planning Decision Making Gmp Cell Culture Chromatography Protein Purification
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