Damir Vidovic - Bellevue WA Reiner Laus - San Carlos CA
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
G01N 3353
US Classification:
435 71, 435 4, 435 723
Abstract:
Anti-human major histocompatibility complex (MHC) class II, HLA-DR-specific monoclonal antibodies which can induce apoptosis of HLA-DR positive cells are disclosed. The antibodies are used to specifically eliminate HLA-DR antigen positive tumor cells by cross-linking of HLA-DR. Also disclosed are methods for treating cancer using such antibodies, and compositions containing them.
Compositions And Methods For Dendritic Cell-Based Immunotherapy
Reiner Laus - Bellevue WA, US Damir Vidovic - Bellevue WA, US Thomas Graddis - Seattle WA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
A61K 39/00
US Classification:
4241851, 4241921, 4242771, 435372, 435375, 530350
Abstract:
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.
Compositions And Methods For Enhancement Of Major Histocompatibility Complex Class I Restricted Antigen Presentation
Reiner Laus - Bellevue WA, US Itzhak Hakim - Palo Alto CA, US Damir Vidović - Bellevue WA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
C07K 1/00 C07K 14/00
US Classification:
530350, 530402, 530403
Abstract:
Compositions and methods for eliciting an in vivo cytotoxic lymphocyte (CTL) response against a modified soluble protein antigen are disclosed. The modified soluble protein antigen comprises an added peptidic sequence which facilitates entry of the modified antigen into antigen presenting cells (APC).
Composition And Method For Producing An Immune Response Against Tumor-Related Antigens
Reiner Laus - Bellevue WA, US Curtis L. Ruegg - Redwood City CA, US Michael H. Shapero - Redwood City CA, US Demao Yang - Mountain View CA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
C07K 5/10
US Classification:
530350, 514 2
Abstract:
Disclosed are a novel prostatic acid phosphatase and corresponding coding region derived from mouse. Also disclosed is a method of producing an immune response against an autologous polypeptide tumor antigen by immunizing a subject with a xenogeneic polypeptide antigen, either alone, as part of a viral antigen construct, or as part of a pulsed dendritic cell preparation.
Compositions And Methods For Enhancement Of Major Histocompatibility Complex Class I Restricted Antigen Presentation
Reiner Laus - Bellevue WA, US Itzhak Hakim - Palo Alto CA, US Damir Vidović - Bellevue WA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
C12N 5/00 C12N 5/06 A61K 39/00
US Classification:
424 937, 424 9371, 435325
Abstract:
Compositions and methods for eliciting an in vivo cytotoxic lymphocyte (CTL) response against a modified soluble protein antigen are disclosed. The modified soluble protein antigen comprises an added peptidic sequence which facilitates entry of the modified antigen into antigen presenting cells (APC).
Compositions And Methods Employing Alternative Reading Frame Polypeptides For The Treatment Of Cancer And Infectious Disease
Thomas Graddis - Seattle WA, US Reiner Laus - Bellevue WA, US Michael Diegel - Covington WA, US Damir Vidovic - Bellevue WA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
A61K 39/00
US Classification:
4241851, 530828
Abstract:
Provided are alternative reading frame (ARF) polypeptides as well as antigen presenting cell (APC) and dendritic cell (DC) based compositions and methods that employ alternative reading frame polypeptides. ARF polypeptides and ARF polypeptide-based compositions and methods are useful in the treatment of cancer and infectious disease.
Compositions And Methods For Dendritic Cell-Based Immunotherapy
Reiner Laus - Bellevue WA, US Damir Vidovic - Bellevue WA, US Thomas Graddis - Seattle WA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
C12N 5/06
US Classification:
435355, 435372, 530300, 530350
Abstract:
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.
Methods For Treating Cancer With A Recombinant Mva Expressing Her-2
Alain Delcayre - San Jose CA, US Reiner Laus - Saratoga CA, US Stefanie Mandl - San Francisco CA, US
Assignee:
BN Immunotherapeutics, Inc. - Mountain View CA
International Classification:
A61K 31/70 A61K 48/00 A01N 43/04
US Classification:
424 932, 514 44 R
Abstract:
The invention relates to compositions, kits, and methods for cancer therapy using recombinant MVA viruses encoding a tumor-associated antigen, such as HER-2, particularly in combination with taxanes. The taxanes can be administered prior to, at the same time as, or after the recombinant MVA virus.
Name / Title
Company / Classification
Phones & Addresses
Reiner Laus President
BN IMMUNOTHERAPEUTICS, INC Commercial Physical Research
2425 Garcia Ave, Mountain View, CA 94043 Mountain View, CA 94043 6506814682, 6506259310
Reiner Laus President
BAVARIAN NORDIC INC Commercial Physical Research · Nonclassifiable Establishments
2425 Garcia Ave, Mountain View, CA 94043 50 California St, San Francisco, CA 94111
Youtube
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