William A. Nugent - Cambridge MA, US Adam R. Looker - Cambridge MA, US Raymond E. Forslund - Natick MA, US Theodore A. Martinot - Jamaica Plain MA, US Cristian L. Harrison - Beverly MA, US Shereen Ibrahim - Cambridge MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 339/06
US Classification:
549 39
Abstract:
The invention provides β-sulfonamide α-keto esters and amides in which the α-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
Processes And Intermediates For Preparing Steric Compounds
Robert Perni - Marlborough MA, US Youssef Bennani - Boston MA, US Gregor Zlokarnik - La Jolla CA, US Gerald Tanoury - Hudson MA, US Minzhang Chen - Acton MA, US Young Jung - Lexington MA, US Raymond Forslund - Natick MA, US Francois Maltais - Tewksbury MA, US
International Classification:
A61K 31/497 C07D 403/02 C07D 413/02 C07D 417/02
US Classification:
514255050, 544405000
Abstract:
A deuterated α-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.
Processes And Intermediates For Preparing Steric Compounds
Gerald Tanoury - Hudson MA, US Minzhang Chen - Acton MA, US Young Jung - Lexington MA, US Raymond Forslund - Natick MA, US
International Classification:
C07J 9/00 C07D 303/36
US Classification:
549553000, 552001000, 552548000, 562585000
Abstract:
This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R, R′and Rare defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
Processes And Intermediates For Producing Aminobenzimidazole Ureas
Raymond Forslund - Natick MA, US Derek Magdziak - Medford MA, US Yong Dong - Wayland MA, US Gerald Tanoury - Hudson MA, US
International Classification:
C07D 401/14
US Classification:
544333
Abstract:
The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of bacterial gyrase and Topoisomerase IV (Topo IV).
Robert B. Perni - Marlborough MA, US Youssef Bennani - Boston MA, US Gregor Zlokarnik - La Jolla CA, US Gerald J. Tanoury - Hudson MA, US Minzhang Chen - Acton MA, US Young Chun Jung - Lexington MA, US Raymond E. Forslund - Natick MA, US Francois Maltais - Tewksbury MA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
A61K 38/04
US Classification:
514 43, 530330
Abstract:
A deuterated α-ketoamido steric specific compound of the formulawherein D denotes a deuterium atom on a steric specific carbon atom.
Preparation Of Protected Alpha-Keto Beta-Amino Esters And Amides
VERTEX PHAMACEUTICALS INCORPORATED - Cambridge MA, US Adam R. Looker - Cambridge MA, US Raymond E. Forslund - Natick MA, US Theodore A. Martinot - Jamaica Plain MA, US Cristian L. Harrison - Beverly MA, US Sheree Ibrahim - Cambridge MA, US
Assignee:
VERTEX PHAMACEUTICALS INCORPORATED - Cambridge MA
International Classification:
C07D 339/06
US Classification:
549 39
Abstract:
The invention provides β-sulfonamide α-keto esters and amides in which the α-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
Processes And Intermediates For Preparing Steric Compounds
VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA, US Minzhang Chen - Shanghai, CN Young Chun Jung - Lexington MA, US Raymond E. Forslund - Natick MA, US
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED - Cambridge MA
This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1wherein the variables R, R′and Rare defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
Nov 2013 to 2000 Senior Manager of OperationsIRONWOOD PHARMACEUTICALS INC Cambridge, MA Mar 2008 to Nov 2013 Scientist/Sr Development Scientist/Sr Development Scientist IIVERTEX PHARMACEUTICALS INC
2007 to 2008 Project managerVERTEX PHARMACEUTICALS INC
2006 to 2007 Lead ChemistVERTEX PHARMACEUTICALS INC Cambridge, MA 2005 to 2006 Scientist I/Scientist II
Education:
BABSON COLLEGE Wellesley, MA 2011 MBAUNIVERSITY OF MARYLAND, College Park 2004 Post DocUNIVERSITY OF ILLINOIS AT CHICAGO Chicago, IL 2003 Doctor in PhilosophyHAMILTON COLLEGE 1998 Bachelor in Chemistry
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