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Rasappa G Arumugham

age ~70

from Lansdale, PA

Also known as:
  • Rasappa Arumugham
  • P Arumugham
  • Rasappa Arumgham
  • Arumugham Rasappa

Rasappa Arumugham Phones & Addresses

  • Lansdale, PA
  • Pomona, NY
  • 15 Elatia Cir, Pittsford, NY 14534
  • 102 Barton Ln, Chapel Hill, NC 27516 • 9199299795
  • 101 Kildaire Rd, Chapel Hill, NC 27516 • 9199299795
  • West Henrietta, NY
  • Rochester, NY
  • 2284 Warner Rd, Lansdale, PA 19446 • 9194756075

Work

  • Position:
    Professional/Technical

Education

  • Degree:
    Graduate or professional degree

Us Patents

  • Antigenic Conjugates Of Conserved Lipopolysaccharides Of Gram Negative Bacteria

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  • US Patent:
    6645503, Nov 11, 2003
  • Filed:
    Mar 9, 1999
  • Appl. No.:
    09/264747
  • Inventors:
    Rasappa G. Arumugham - Pittsford NY
    Michael A. Apicella - Solon IA
    Bradford W. Gibson - Berkeley CA
  • Assignee:
    Wyeth Holdings Corporation - Madison NJ
  • International Classification:
    A61K 39385
  • US Classification:
    42419711, 4241941, 4241931, 4241841, 4242031, 4242341, 4242501, 514 23, 514 54, 5361231
  • Abstract:
    Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein the conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of the lipopolysaccharide, the conjugate eliciting a cross reactive immune response against heterologous strains of the gram negative bacteria.
  • Non-Toxic Mutants Of Pathogenic Gram-Negative Bacteria

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  • US Patent:
    7005129, Feb 28, 2006
  • Filed:
    Nov 27, 1996
  • Appl. No.:
    09/077572
  • Inventors:
    Michael A. Apicella - Solon IA,
    Melvin G. Sunshine - Iowa City IA,
    Na-Gyong Lee - Incheon,
    Bradford W. Gibson - Berkeley CA,
    Rasappa Arumugham - Pittsford NY,
  • Assignee:
    University of Iowa Research Foundation - Iowa City IA
    The Regents of the University of California - Oakland CA
  • International Classification:
    A61K 39/385
    A61K 39/02
    A61K 39/102
    C07H 1/00
    G01N 33/53
  • US Classification:
    42419711, 4242341, 4242561, 4241931, 424831, 4241841, 435547, 5361271, 5361231
  • Abstract:
    A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.
  • Non-Toxic Mutants Of Pathogenic Gram-Negative Bacteria

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  • US Patent:
    7510717, Mar 31, 2009
  • Filed:
    Jan 12, 2006
  • Appl. No.:
    11/330527
  • Inventors:
    Michael A. Apicella - Solon IA,
    Melvin G. Sunshine - Iowa City IA,
    Na-Gyong Lee - Incheon,
    Rasappa Arumugham - Pittsford NY,
    Bradford W. Gibson - Berkeley CA,
  • Assignee:
    University of Iowa Research Foundation - Iowa City IA
  • International Classification:
    A61K 39/385
    A61K 39/116
    A61K 39/02
    A61K 39/102
    A61K 39/00
    A01N 43/04
    C07H 1/00
  • US Classification:
    42419711, 4242561, 4242341, 4242031, 4241841, 514 23, 5361231
  • Abstract:
    A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.
  • A-Β Immunogenic Peptide Carrier Conjugates And Methods Of Producing Same

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  • US Patent:
    8227403, Jul 24, 2012
  • Filed:
    Dec 17, 2004
  • Appl. No.:
    10/583503
  • Inventors:
    Rasappa G. Arumugham - Chapel Hill NC,
    A. Krishna Prasad - Chapel Hill NC,
    Michael Hagen - Pittsford NY,
  • Assignee:
    Wyeth LLC - Madison NJ
    Janssen Alzheimer Immunotherapy - Dublin
  • International Classification:
    A61K 38/00
    C07K 17/00
  • US Classification:
    514 11, 514 212, 525 5411
  • Abstract:
    The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
  • Antigenic Conjugates Of Conserved Lipopolysaccharides Of Gram Negative Bacteria

    view source
  • US Patent:
    20040052804, Mar 18, 2004
  • Filed:
    Aug 19, 2003
  • Appl. No.:
    10/643314
  • Inventors:
    Rasappa Arumugham - Chapel Hill NC,
    Michael Apicella - Solon IA,
    Bradford Gibson - Berkeley CA,
  • Assignee:
    Wyeth Holdings Corporation - Madison NJ
  • International Classification:
    A61K039/00
    A61K039/38
  • US Classification:
    424/184100
  • Abstract:
    Antigenic conjugates are provided which comprise a carrier protein covalently bonded to the conserved portion of a lipopolysaccharide of a gram negative bacteria, wherein said conserved portion of the lipopolysaccharide comprises the inner core and lipid A portions of said lipopolysaccharide, said conjugate eliciting a cross reactive immune response against heterologous strains of said gram negative bacteria.
  • Immunogenic Peptide Carrier Conjugates And Methods Of Producing Same

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  • US Patent:
    20070134762, Jun 14, 2007
  • Filed:
    Dec 17, 2004
  • Appl. No.:
    10/583464
  • Inventors:
    Rasappa Arumugham - Chapel Hill NC,
    A. Prasad - Chapel Hill NC,
  • International Classification:
    C12Q 1/68
    C12P 21/06
  • US Classification:
    435069100, 435006000
  • Abstract:
    The present invention is directed to methods of producing conjugates of peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
  • A-Beta Immunogenic Peptide Carrier Conjugates And Methods Of Producing Same

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  • US Patent:
    20080145373, Jun 19, 2008
  • Filed:
    Aug 20, 2007
  • Appl. No.:
    11/841919
  • Inventors:
    Rasappa G. Arumugham - Chapel Hill NC,
    A. Krishna Prasad - Chapel Hill NC,
  • Assignee:
    Elan Pharmaceuticals, Inc. - South San Francisco CA
    Wyeth - Madison NJ
  • International Classification:
    A61K 39/385
    A61P 43/00
  • US Classification:
    4241791
  • Abstract:
    The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via capping, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
  • Automated Colorimetric Polysaccharide Assays

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  • US Patent:
    20080227207, Sep 18, 2008
  • Filed:
    Mar 13, 2008
  • Appl. No.:
    12/048010
  • Inventors:
    Vincent E. Turula - Holly Springs NC,
    Shaune Walters - Raleigh NC,
    Suddham Singh - Chapel Hill NC,
    Rasappa Arumugham - Chapel Hill NC,
  • Assignee:
    Wyeth - Madison NJ
  • International Classification:
    G01N 33/50
  • US Classification:
    436 43
  • Abstract:
    A method of automated determination of saccharide concentration is provided herein. The method includes preparing one or more saccharide standards and one or more diluted polysaccharide test samples, transferring a portion of the one or more saccharide standards and the one or more diluted polysaccharide test samples along with a diluent to a series of wells in a multiwell plate, transferring a portion of an acid reagent to the series of wells in the multiwell plate, mixing the contents of the series of wells in the multiwell plate, heating and cooling the contents of the series of wells in the multiwell plate, shaking the multiwell plate, and measuring the radiant energy absorbance of the contents of the series of wells in the multiwell plate, where all steps are performed in the absence of human intervention.

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