Raisa N Nagorny

US Patent:

6723552, Apr 20, 2004

Filed:

Jun 20, 2001

Appl. No.:

09/885478

Inventors:

John A. Salon - Santa Paula CA
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - Woodstock NY

Assignee:

Synaptic Pharmaceutical Corporation - Paramus NJ

International Classification:

C12N 121

US Classification:

4352523, 4353201, 435348, 4352551, 435361, 435357, 435365, 435369, 435358, 435254, 536 235, 530350

Abstract:

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

US Patent:

7393655, Jul 1, 2008

Filed:

Apr 15, 2004

Appl. No.:

10/825581

Inventors:

John A. Salon - Santa Paula CA, US
Thomas M. Laz - Parlin NJ, US
Raisa Nagorny - Fair Lawn NJ, US
Amy F. Wilson - Woodstock NY, US

Assignee:

H. Lundbeck A/S - Valby-Copenhagen

International Classification:

G01N 33/53
C12N 15/00
C07K 14/00

US Classification:

435 721, 435 71, 435 72, 4352523, 4353201, 435361, 435336, 435357, 435365, 530350, 536 235

Abstract:

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

US Patent:

20030130493, Jul 10, 2003

Filed:

Aug 26, 2002

Appl. No.:

10/228762

Inventors:

James Bonini - Oakland NJ, US
Ling Huang - Kearny NJ, US
Beth Borowsky - Flemington NJ, US
John Salon - Santa Paula CA, US
Amy Wilson - Woodstock NY, US
Raisa Nagorny - Fair Lawn NJ, US

International Classification:

C07H021/04
C12Q001/68
C07K014/705
C12P021/02
C12N005/06
A61K038/17

US Classification:

536/023500, 530/350000, 514/012000, 435/006000, 435/069100, 435/320100, 435/325000

Abstract:

This invention provides isolated nucleic acids encoding mammalian Edg7 receptors, purified mammalian Edg7 receptors, vectors comprising nucleic acid encoding mammalian Edg7 receptors, cells comprising such vectors, antibodies directed to mammalian Edg7 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian Edg7 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian Edg7 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian Edg7 receptors, methods of isolating mammalian Edg7 receptors, methods of treating an abnormality that is linked to the activity of the mammalian Edg7 receptors, as well as methods of determining binding of compounds to mammalian Edg7 receptors, methods of identifying agonists and antagonists of Edg7 receptors, and agonists and antagonists so identified.

US Patent:

20040038855, Feb 26, 2004

Filed:

Jan 14, 2003

Appl. No.:

10/341751

Inventors:

John Salon - Santa Paula CA, US
Thomas Laz - Kennilworth NJ, US
Raisa Nagorny - Fair Lawn NJ, US
Amy Wilson - New York NY, US
Douglas Craig - Emerson NJ, US

International Classification:

A61K031/00

US Classification:

514/001000

Abstract:

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention further provides a method of treating a subject suffering from urinary incontinence which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's urinary incontinence.

US Patent:

62216139, Apr 24, 2001

Filed:

Dec 31, 1998

Appl. No.:

9/224426

Inventors:

John A. Salon - Montclair NJ
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - New York NY

Assignee:

Synaptic Pharmaceutical Corporation - Paramus NJ

International Classification:

G01N 3353

US Classification:

435 71

Abstract:

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

US Patent:

62911953, Sep 18, 2001

Filed:

Jan 6, 2000

Appl. No.:

9/478602

Inventors:

John A. Salon - Montclair NJ
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - New York NY

Assignee:

Synaptic Pharmaceutical Corporation - Paramus NJ

International Classification:

G01N 3353

US Classification:

435 721

Abstract:

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

US Patent:

62216163, Apr 24, 2001

Filed:

Jan 6, 2000

Appl. No.:

9/478601

Inventors:

John A. Salon - Montclair NJ
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - New York NY

Assignee:

Synaptic Pharmaceutical Corporation - Paramus NJ

International Classification:

G01N 3353

US Classification:

435 71

Abstract:

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.