Ping X Xin

US Patent:

20060269530, Nov 30, 2006

Filed:

Feb 23, 2004

Appl. No.:

10/552914

Inventors:

Gary Clawson - Bathesda MD, US
Wei-Hua Pan - Hummelstown PA, US
Ping Xin - Hummelstown PA, US

Assignee:

THE PENN STATE RESEARCH FOUNDATION - University Park PA

International Classification:

A61K 48/00
C07H 21/02
C12N 5/08
C12N 15/86
C12N 7/00

US Classification:

424093210, 514044000, 435366000, 435235100, 435456000, 536023100

Abstract:

The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.

US Patent:

20100036107, Feb 11, 2010

Filed:

Oct 13, 2009

Appl. No.:

12/578035

Inventors:

Gary A. Clawson - Bethesda MD, US
Wei-Hua Pan - Hummelstown PA, US
Ping Xin - Hummelstown PA, US

International Classification:

C07H 21/02
C07H 21/04

US Classification:

536 245

Abstract:

The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.