Paul J Yaworsky

US Patent:

7416849, Aug 26, 2008

Filed:

May 13, 2002

Appl. No.:

10/477173

Inventors:

Kristina Allen - Hopkinton MA, US
Anthony Anisowicz - West Newton MA, US
James R. Graham - Arlington MA, US
Arturo Morales - Arlington MA, US
Paul J. Yaworsky - Rockland MA, US
Wei Liu - Sudbury MA, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA
Wyeth - Madison NJ

International Classification:

G01N 33/50
C12N 1/19
C12N 1/21
C12N 15/11
C12N 15/12
C12N 15/63
C12N 5/10
C07K 14/00
C07K 14/435

US Classification:

435 71, 4353201, 4352523, 43525411, 435325, 536 231, 536 235, 530350, 530351

Abstract:

The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

US Patent:

7700101, Apr 20, 2010

Filed:

Jan 22, 2007

Appl. No.:

11/655924

Inventors:

Kristina M. Allen - Hopkinton MA, US
Anthony Anisowicz - West Newton MA, US
Veronique Damagnez - Framingham MA, US
John A. Robinson - Downington PA, US
Paul J. Yaworsky - Rockland MA, US
Bheem M. Bhat - West Chester PA, US

Assignee:

Wyeth - Madison NJ
Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

A61K 39/395

US Classification:

4241391, 4241301, 4241331, 4241411, 4241451, 4241361

Abstract:

The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.

US Patent:

7754689, Jul 13, 2010

Filed:

Jun 1, 2007

Appl. No.:

11/809383

Inventors:

Zhijian Lu - Bedford MA, US
Wei Liu - Lexington MA, US
Jimin Zhang - Chestnut Hill MA, US
Paul John Yaworsky - Rockland MA, US
Stephane H. Olland - Arlington MA, US
Christopher Todd Brown - Lowell MA, US
Emily Sheng-ming Shen - West Chester PA, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 38/00
A61K 38/24
A01N 37/18
C07K 1/00
C07K 14/00
C07H 21/04

US Classification:

514 12, 530399, 530350, 530417, 536 235, 514 2

Abstract:

Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.

US Patent:

20060127388, Jun 15, 2006

Filed:

Dec 9, 2005

Appl. No.:

11/299324

Inventors:

Michael Cain - Stratham NH, US
Paul Yaworsky - Rockland MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 38/45
C07H 21/04
C12P 21/06
C12N 9/12
C12N 5/08
C07K 16/40

US Classification:

424094500, 435069100, 435194000, 435320100, 435366000, 536023200, 530388260

Abstract:

The present invention provides GSK3β variants, including splice variants expressed in bone or other tissues. These variants have a broad range of functional activity, from inhibiting the Wnt pathway to activating the pathway as dominant-negatives of the full-length GSK3β. These variants, as well as their modulators, can be used to treat diseases that involve GSK3β or its associated signaling pathways.

US Patent:

20090087431, Apr 2, 2009

Filed:

Jul 2, 2008

Appl. No.:

12/166464

Inventors:

Paul John YAWORSKY - Boston MA, US
Erica Ann Smith - New London CT, US
Michael John Cain - Exeter NH, US
John Allen Robinson - Downingtown PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 39/395
A61K 31/7105
A61K 38/16
A61P 19/08
C12Q 1/68
C07H 21/02

US Classification:

4241331, 4241301, 514 44, 514 12, 435 6, 536 231

Abstract:

The invention provides methods for treating or preventing bone and cartilage disorders comprising administering to a mammal an inhibitor of Axl gene expression or an inhibitor of Axl protein activity.

US Patent:

20090136507, May 28, 2009

Filed:

Jul 18, 2008

Appl. No.:

12/219294

Inventors:

Kristina Allen - Hopkinton MA, US
Anthony Anisowicz - West Newton MA, US
James R. Graham - Arlington MA, US
Arturo Morales - Arlington MA, US
Paul J. Yaworsky - Rockland MA, US
Wei Liu - Sudbury MA, US

Assignee:

Oscient Pharmaceuticals - Waltham MA
Wyeth - Madison NJ

International Classification:

A61K 39/395
C07K 16/18

US Classification:

4241391, 5303879, 5303873

Abstract:

The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

US Patent:

20090202474, Aug 13, 2009

Filed:

Nov 19, 2008

Appl. No.:

12/273945

Inventors:

Priya CHOCKALINGAM - Arlington MA, US
Manas K. MAJUMDAR - Audubon PA, US
Debra D. PITTMAN - Windham NH, US
Julia BILLIARD - Collegeville PA, US
Edward Roland LAVALLIE - Harvard MA, US
Jeffrey L. FELDMAN - Arlington MA, US
Vishnuvardhan DAESETY - Andover MA, US
Robert MORAN - Schwenksville PA, US
Elisabeth A. MORRIS - Sherborn MA, US
Paul YAWORSKY - Boston MA, US

Assignee:

WYETH - Madison NJ

International Classification:

A61K 38/20
G01N 33/53
G01N 33/68
C12Q 1/37
C12Q 1/00
A61P 29/00
A61K 38/16
C07H 21/00
C12N 15/63
C12N 5/08
C12N 5/06
C12N 1/19
C12N 1/21

US Classification:

424 852, 436501, 436 86, 435 23, 435 4, 435 24, 514 12, 536 231, 4353201, 435366, 435369, 435358, 435325, 435348, 4352542, 4352523

Abstract:

Methods of screening for agents for treating inflammatory diseases are provided. The methods involve screening for agents that modulate the activity or expression of GPR64, which has been discovered herein to play a role in inflammatory diseases. Methods for treating an inflammatory disease, as well as methods of modulating the activity or expression of GPR64, methods of screening for an inflammatory disease in a subject, pharmaceutical compositions, a nucleic acid variant, and antibodies are also provided.

US Patent:

20100286071, Nov 11, 2010

Filed:

Jun 17, 2010

Appl. No.:

12/817718

Inventors:

Zhijian Lu - Bedford MA, US
Wei Liu - Lexington MA, US
Jimin Zhang - Chestnut Hill MA, US
Paul John Yaworsky - Boston MA, US
Stephane H. Olland - Arlington MA, US
Christopher Todd Brown - Lowell MA, US
Emily Sheng-ming Shen - West Chester PA, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 38/16
C07K 14/00
C07K 7/08
C07K 1/16
A61K 38/10
A61P 17/02

US Classification:

514 213, 530325, 530326, 530324, 530417, 514 214

Abstract:

Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.