Texas A&M University System
Vice Chancellor and Dean
Cornell University Jul 1994 - Feb 2018
College of Human Ecology, Professor, Division Director
Annual Reviews Jul 1994 - Feb 2018
Co-Editor of Annual Reviews of Nutrition
American Society For Nutrition Jul 1994 - Feb 2018
Past President
Uc Berkeley 1991 - 1994
Post-Doctoral Associate
Education:
Medical College of Virginia 1987 - 1991
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy, Molecular Biophysics
Saint Joseph's University 1983 - 1987
Bachelors, Bachelor of Science, Chemistry
Skills:
Nutrition Genomics Cell Biology Science Public Health Lifesciences Physiology Metabolism Biochemistry Epidemiology Microbiology Animal Models Translational Research Genetics Life Sciences Biostatistics Systems Biology Higher Education Cell Culture Protein Chemistry In Vitro Microscopy Qpcr Pcr Western Blotting Vitamins Neuroscience Academic Administration Folate
The present invention relates to a method of screening test substances for chemotherapeutic activity or for efficacy in treating cardiovascular disease by providing one or more cells transformed with a nucleic acid molecule encoding methenyltetrahydrofolate synthetase, contacting the cells with test substance(s), and identifying those test substances which modulate methenyltetrahydrofolate synthetase expression as candidates for such therapeutic use. Another aspect of the present invention relates to a method of measuring folate status in a sample by measuring methenyltetrahydrofolate synthetase expression or activity and/or catecholamine activity in the sample, all of which are correlated to folate status in the sample. The present invention can also be used to treat or prevent cancer or cardiovascular disease in a subject by administering to the subject a substance which modulates methenyltetrahydrofolate synthetase expression or activity and/or catecholamine activity.
Use Of Uridine And Deoxyuridine To Treat Folate-Responsive Pathologies
Patrick J. Stover - Ithaca NY, US Martha S. Field - Burdett NY, US
Assignee:
CORNELL UNIVERSITY - Ithaca NY
International Classification:
A61K 31/7072 A61N 5/10 A23L 1/30 A61K 45/06
US Classification:
514 50, 600 1
Abstract:
The present invention relates to a pharmaceutical or dietary composition comprising deoxyuridine and a pharmaceutically or dietetically suitable carrier. Another aspect of the present invention relates to a method of supplementing the dietary needs of a subject. This method includes administering to the subject a dietary supplementing effective amount of deoxyuridine. Yet another aspect of the present invention relates to a method of treating cancer in a subject. This method includes selecting a subject having cancer and administering to the selected subject a therapeutically effective amount of uridine, thereby treating the cancer in the selected subject.