- Austin TX, US Hong Zan - San Antonio TX, US Paolo Casali - San Antonio TX, US
International Classification:
A01K 67/027
Abstract:
Described herein are transgenic mice for testing immunogenicity and protective efficacy of a wide variety of therapeutic agents and vaccines, determining allograft rejection, and developing monoclonal antibodies and generating hybridomas. Methods of generating a transgenic mouse is also described. Described herein are mouse models capable of expressing B cell, a T cell, a monocyte, a macrophage, a dendritic cell, a NK cell, a iNKT cell, an innate lymphoid cell, a microglia cell, a red blood cell, which can develop into a functional human immune system.
Resumes
Zachry Distinguished Professor And Chairman, Department Of Microbiology, Immunology And Molecular Genetics
University of Texas Long School of Medicine
Zachry Distinguished Professor and Chairman, Department of Microbiology, Immunology and Molecular Genetics
Uc Irvine 2003 - 2013
Donald Bren Professor of Medicine, Mol Biology and Biochemistry and Director, Institute For Immunology
Cornell University Weill Medical College 1994 - 2003
Professor of Pathology and Laboratory Medicine
Nyu School of Medicine 1989 - 1994
Associate Professor of Pathology and Kaplan Cancer Scholar
Education:
Università Degli Studi Di Milano 1977 - 1984
University of Geneva 1976 - 1978
Università Degli Studi Di Milano 1973 - 1976
Università Degli Studi Di Milano 1967 - 1974
Skills:
Immunology Molecular Biology Cancer Biochemistry Microbiology Western Blotting Laboratory Cell Biology Qpcr Elisa Flow Cytometry Immunohistochemistry In Vivo Cell Culture Molecular Cloning Fluorescence Microscopy Pcr Cell Tissue Culture Genetics Genomics Microscopy Life Sciences Drug Discovery Neuroscience Research Lifesciences Biology Pathology Medicine Laboratory Medicine Science Molecular Genetics