Nicholas A Kotov

Author:

Nicholas A. Kotov

ISBN #:

0824725247

US Patent:

7045087, May 16, 2006

Filed:

Mar 27, 2001

Appl. No.:

09/818001

Inventors:

Nicholas A. Kotov - Stillwater OK, US

Assignee:

The Board of Regents for Oklahoma State University - Stillwater OK

International Classification:

B29C 41/22

US Classification:

264255, 264304, 264305, 264306, 264307, 264313, 264334

Abstract:

A method for the layer-by-layer assembly of a free standing thin film includes the steps of preparing a support with a suitable substrate; forming a thin film having a plurality of layers onto the substrate utilizing a layer-by-layer assembly process; removing the substrate and thin film from the support; and separating the substrate from the thin film. Various compounds improving the strength, flexibility, tension and other mechanical properties may be included in the assembly to improve the structural quality of the film. Similar effect may also be achieved by cross-linking the applied layers.

US Patent:

7329415, Feb 12, 2008

Filed:

Mar 12, 2003

Appl. No.:

10/387190

Inventors:

John Martin Lally - Lilburn GA, US
Nicholas Kotov - Stillwater OK, US

Assignee:

Novartis AG - Basel

International Classification:

A61K 9/00
A61K 424/45

US Classification:

424429, 424450, 623 659, 623 657

Abstract:

The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.

US Patent:

7438953, Oct 21, 2008

Filed:

Jun 6, 2003

Appl. No.:

10/457024

Inventors:

Nicholas A. Kotov - Stillwater OK, US
Zhiyong Tang - Stillwater OK, US
Arif A. Mamedov - Stillwater OK, US

Assignee:

The Board of Regents for Oklahoma State University - Stillwater OK

International Classification:

B05D 1/18

US Classification:

4274301, 427314, 427 21, 427171, 427299

Abstract:

A method for the assembly of a thin film containing highly anisotropic colloids that includes the steps of immersing a substrate in a first solution or dispersion comprising a first substance, wherein the first substance has an affinity for the substrate. Then, immersing the substrate in a second solution or dispersion comprising a second substance, wherein the second substance has an affinity for the first substance. A least one of the first substance and the second substance is a highly anisotropic colloid having at least one dimension differing from the others by a ratio of at least 1:1. 5. The method incorporates highly anisotropic colloids using a layer-by-layer process that circumvents the tendency for separation of nanotubes at high nanotube loadings. Additionally, the method incorporates aligned highly anisotropic colloids and provides a method for carbon nanotube alignment, which among other advantages makes possible the preparation of unique criss-crossed composites.

US Patent:

7534610, May 19, 2009

Filed:

Jun 12, 2003

Appl. No.:

10/460059

Inventors:

Nicholas A. Kotov - Stillwater OK, US
Shaopeng Wang - Stillwater OK, US

Assignee:

The Board of Regents for Oklahoma State University - Stillwater OK

International Classification:

C12N 5/00

US Classification:

435402, 435325, 435366, 435395

Abstract:

A cell growth matrix for optimizing 3D organization nutrient delivery, controlling release of differentiation factors and facilitating attachment of cells to a scaffold Colloidal crystals and inverted colloidal crystals are used to form an ordered structure for use as a scaffold for tissue engineering. The porosity of the cell growth matrix may be modified by the selection of particles of appropriate diameter. Further, the surface of colloidal crystals can be easily modified to accommodate many organic species including biomolecules. Layer-by-layer materials are used for tissue engineering to control cell development by using sequential layering of bioactive species wherein the number and order of LBL layers deposited between layers containing a particular protein are controlled. LBL may also be used for timed release of bioactive species. Increased control differentiation factors release and control of cell attachments to the scaffold are achieved to better mimic natural tissue development.

US Patent:

7863038, Jan 4, 2011

Filed:

Mar 31, 2003

Appl. No.:

10/403845

Inventors:

Massoud Motamedi - Houston TX, US
Nicholas A. Kotov - Stillwater OK, US
James P. Wicksted - Stillwater OK, US
Rinat Esenaliev - League City TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12M 1/36

US Classification:

4352878, 4352877, 4352887, 436518, 436528, 427 211, 427 213, 427 222

Abstract:

A new class of biosensors and methods for making and using same are disclosed. The biosensors are multi-layered membrane composites, where at least one layer is prepared by the layer-by-layer process and at least one layer is responsive to changes is a property of a biological system such as changes in the concentration of an atom, ion, molecule or molecular assembly. Because the biosensors are multi-layered, a single biosensor is capable monitor a number of different properties of a biological system simultaneously. The biosensors are monitored by systems that impinge an excitation waveform on the biosensors and analyze a reflected and/or a transmitted resultant waveform. Additionally, the biosensors can be associated with field activated electronic components so that implantable, self-contained analytical devices can be constructed and monitored by field generators, where data is transmitted to an analyzer after field activation.

US Patent:

7897876, Mar 1, 2011

Filed:

Apr 8, 2010

Appl. No.:

12/756603

Inventors:

Thomas K. Tsotsis - Orange CA, US
Nicholas A. Kotov - Ypsilanti MI, US

Assignee:

The Boeing Company - Chicago IL

International Classification:

H01B 5/00

US Classification:

1741261, 1741262

Abstract:

A conductive wire includes an aramid fiber and at least one layer attached about the aramid fiber, the at least one layer including at least one of aligned carbon nanotubes and graphene platelets.

US Patent:

7901706, Mar 8, 2011

Filed:

Oct 31, 2007

Appl. No.:

11/981208

Inventors:

John Martin Lally - Lilburn GA, US
Nicholas Kotov - Stillwater OK, US

Assignee:

Novartis AG - Basel

International Classification:

A61K 9/00
A61K 9/127

US Classification:

424429, 424450, 623 657, 623 659

Abstract:

The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.

US Patent:

8080183, Dec 20, 2011

Filed:

May 30, 2006

Appl. No.:

11/915591

Inventors:

Nicholas Kotov - Ypsilanti MI, US
Alexander Govorov - Athens OH, US

Assignee:

Ohio University - Athens OH

International Classification:

H01B 1/02
H01B 1/04
H01B 1/06

US Classification:

2525194, 252512, 2525195, 977724, 977810, 977813

Abstract:

A nanoscale sensing device from different types of nanoparticles (NPs) and nanowires (NWs) connected by molecular springs. The distance between the nanoscale colloids reversibly changes depending on conditions or analyte concentration and can be evaluated by fluorescence measurements.