James C. Leiter - Woodstock VT, US Mykyta M. Chernov - Lebanon NH, US David W. Roberts - Lyme NH, US
Assignee:
THE TRUSTEES OF DARTMOUTH COLLEGE - Hanover NH
International Classification:
A61N 1/36
US Classification:
607 45
Abstract:
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.
Method And Apparatus Of Pulsed Infrared Light For The Inhibition Of Central Nervous System Neurons
Jonathan Cayce - Nashville TN, US Robert Friedman - Nashville TN, US Anna Roe - Nashville TN, US E. Duco Jansen - Nashville TN, US Mykyta Chernov - Nashville TN, US Peter E. Konrad - Old Hickory TN, US
Assignee:
VANDERBILT UNIVERSITY - Nashville TN
International Classification:
A61N 5/067
US Classification:
607 89
Abstract:
Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS.