Miroslav M Klain

US Patent:

6475186, Nov 5, 2002

Filed:

Dec 26, 2000

Appl. No.:

09/749987

Inventors:

Peter Safar - Pittsburgh PA 15234
S. William Stezoski - Pittsburgh PA 15239
Miroslav Klain - Pittsburgh PA 15241

International Classification:

A61M 2900

US Classification:

60410105, 60410203, 604917

Abstract:

A cardiopulmonary bypass system includes an aortic balloon cannula and a fluid flow cannula configured for connection to a cardiopulmonary bypass pump. The aortic balloon cannula includes an elongated tube device with first and second inflatable balloons mounted on the tube device and first and second lumen sized to communicate blood from the cardiopulmonary bypass pump to the patients aorta. The cardiopulmonary bypass pump is configured to selectively deliver blood to the patient through the aortic balloon cannula and/or the fluid flow cannula at first, second and third temperatures.

US Patent:

53838548, Jan 24, 1995

Filed:

Aug 19, 1992

Appl. No.:

7/932212

Inventors:

Peter Safar - Pittsburgh PA
S. William Stezoski - Pittsburgh PA
Miroslav Klain - Pittsburgh PA

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61M 2900

US Classification:

604 98

Abstract:

The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a first cannula assembly means for withdrawing blood from a patient, (ii) a pump means connected to the first cannula assembly means for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing means connected to the pump means to transport the patient's blood away from the pump means. The apparatus further comprises (iv) oxygenator means for receiving blood from the first tubing means and for oxygenating the blood and (v) second cannula assembly means connected to the oxygenator means for returning the oxygenated blood to the patient. The apparatus is portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others.

US Patent:

59065885, May 25, 1999

Filed:

Aug 11, 1997

Appl. No.:

8/909380

Inventors:

Peter Safar - Pittsburgh PA
S. William Stezoski - Pittsburgh PA
Miroslav Klain - Pittsburgh PA

Assignee:

Cardeon Corporation - Cupertino CA

International Classification:

A61M 3100

US Classification:

604 64

Abstract:

The selective and differential perfusion method includes withdrawing blood through a cannula introduced into a patient's blood vessel. The temperature of such blood is controlled and flowed through an arterial cannula introduced into a selected arterial vessel of the patient for a sufficient time and at a sufficient flow rate to change the temperature of at least a portion of the patient's body. An aortic balloon catheter is introduced into the aorta of the patient to establish fluid communication through the catheter lumen between an external location and an aortic location which is disposed in a preferential flow relationship with a selected branch artery of the aorta leading to a selected region of the patient's body. A balloon mounted on the exterior of said aortic catheter is positioned at a balloon location spaced longitudinally from the aortic location and inflated to resist blood flow while a fluid is communicated through the catheter lumen between the external location and the aortic location. The aortic balloon catheter may further include a second lumen introduced into the aorta to establish a preferential flow relationship with a second branch artery leading to a second region of the patient's body and wherein the balloon location is disposed between the selected branch artery and the second branch artery.

US Patent:

58793160, Mar 9, 1999

Filed:

Apr 10, 1997

Appl. No.:

8/835662

Inventors:

Peter Safar - Pittsburgh PA
S. William Stezoski - Pittsburgh PA
Miroslav Klain - Pittsburgh PA

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61M 3700

US Classification:

604 4

Abstract:

The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a first cannula assembly means for withdrawing blood from a patient, (ii) a pump means connected to the first cannula assembly means for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing means connected to the pump means to transport the patient's blood away from the pump means. The apparatus further comprises (iv) oxygenator means for receiving blood from the first tubing means and for oxygenating the blood and (v) second cannula assembly means connected to the oxygenator means for returning the oxygenated blood to the patient. The apparatus is portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others.

US Patent:

53083202, May 3, 1994

Filed:

Dec 28, 1990

Appl. No.:

7/637565

Inventors:

Peter Safar - Pittsburgh PA
S. William Stezoski - Pittsburgh PA
Miroslav Klain - Pittsburgh PA

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61M 114

US Classification:

604 4

Abstract:

The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a first cannula assembly means for withdrawing blood from a patient, (ii) a pump means connected to the first cannula assembly means for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing means connected to the pump means to transport the patient's blood away from the pump means. The apparatus further comprises (iv) oxygenator means for receiving blood from the first tubing means and for oxygenating the blood and (v) second cannula assembly means connected to the oxygenator means for returning the oxygenated blood to the patient. The apparatus is portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to include one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others.

US Patent:

58205934, Oct 13, 1998

Filed:

Apr 25, 1996

Appl. No.:

8/637861

Inventors:

Peter Safar - Pittsburgh PA
S. William Stezoski - Pittsburgh PA
Miroslav Klain - Pittsburgh PA

Assignee:

University of Pittsburg of the Commonwealth System of Higher Education - Pittsburg PA

International Classification:

A61M 2900

US Classification:

604 96

Abstract:

An aortic balloon catheter including an elongated tube device formed with a first lumen sized to communicate blood between an aortic lumen of an adult human patient and a location external to the aortic lumen. Mounted on the tube device is an inflatable balloon which is sized to resist or block blood flow through the aortic lumen. The associated method of using the aortic balloon catheter includes introducing the catheter into the aortic lumen of an adult human, positioning the first lumen and the balloon, inflating the balloon and withdrawing and perfusing fluids through the first lumen.

US Patent:

61651621, Dec 26, 2000

Filed:

Sep 14, 1998

Appl. No.:

9/152589

Inventors:

Peter Safar - Pittsburgh PA
S. William Stezoski - Pittsburgh PA
Miroslav Klain - Pittsburgh PA

Assignee:

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

A61M 3100

US Classification:

604508

Abstract:

What is disclosed is a portable and modular cardiopulmonary bypass apparatus and method. The apparatus includes (i) a first cannula assembly for withdrawing blood from a patient, (ii) a pump connected to the first cannula assembly for receiving the withdrawn blood and for moving the blood through the apparatus, and (iii) a first tubing connected to the pump to transport the patient's blood away from the pump. The apparatus also includes (iv) an oxygenator for receiving blood from the first tubing and for oxygenating the blood and (v) a second cannula assembly connected to the oxygenator for returning the oxygenated blood to the patient. The apparatus may be portable so that it can be used by medical personnel anywhere. In addition, the apparatus is adapted to included one or more modules for conditioning the blood, such as modules that include a heat exchanger, blood purifier, plasma and blood cell apheresis device and others. An aortic balloon catheter is also provided.