Maurice O Okello

US Patent:

20120282218, Nov 8, 2012

Filed:

Dec 7, 2010

Appl. No.:

13/513448

Inventors:

Vasu Nair - Althens GA, US
Maurice O. Okello - Athens GA, US
Abdumalik A. Nishonov - Boulder CO, US
Sanjaykumar Mishra - Pune, IN

Assignee:

University of Georgia Research Foundation Inc. - Athens GA

International Classification:

A61K 31/4439
A61K 31/4412
C07D 401/12
A61K 31/7052
A61K 31/52
A61K 31/715
A61K 31/675
A61K 38/21
A61K 39/395
A61K 38/19
A61K 38/20
A61K 31/522
A61K 38/05
A61K 31/7072
A61K 31/7076
A61K 31/708
A61K 31/7068
A61K 31/7125
A61K 38/13
A61K 31/7048
A61P 31/18
A61P 37/02
C07D 213/64

US Classification:

424 852, 546291, 514346, 5462784, 514343, 514 43, 5142634, 514 54, 514 81, 424 857, 4241581, 424 856, 424 855, 424 851, 51426337, 514 38, 514 50, 514 46, 514 45, 514 49, 514 44 A, 514 27

Abstract:

New chiral and achiral oxy-substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers and geometric isomers. These complex carboxamides are designed as inhibitors of HIV replication through inhibition of HIV integrase. The compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti-HIV compounds (including other anti-HIV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.

US Patent:

20150050237, Feb 19, 2015

Filed:

Mar 13, 2013

Appl. No.:

14/388404

Inventors:

- ATHENS GA, US
Maurice O. Okello - Athens GA, US
Machhindra G. Gund - Athens GA, US
Byung I. Seo - Hoschton GA, US
Pankajkumar R. Singh - Thane, IN
Naveen K. Mangu - Athens GA, US

International Classification:

C07D 401/12
A61K 31/496
A61K 45/06
C07D 213/64

US Classification:

424 852, 544365, 51425312, 544364, 51425309, 514 211, 424 857, 4241581, 424 856, 424 855

Abstract:

The present invention relates to the field of anti-mycobacterial therapeutics, in particular the treatment of tuberculosis, especially including pulmonary multidrug-resistant tuberculosis (MDR-TB), with applications in extensively drug-resistant tuberculosis (XDR-TB) and extremely drug-resistant tuberculosis (XXDR-TB), preferably in combination therapy.