Matthew M Cadin from 303 Parsons Dr, Syracuse, NY 13219, age 51, Phone: 3154682757

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor
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US Patent:

8222009, Jul 17, 2012
Filed:

Jun 17, 2010
Appl. No.:

12/817370
Inventors:

Michael Politino - Syracuse NY, US
Matthew M. Cadin - Auburn NY, US
Paul M. Skonezny - Baldwinsville NY, US
Jason G. Chen - Manlius NY, US
Assignee:

Bristol-Myers Squibb Company - Princeton NJ
International Classification:

C12P 13/00
C12P 1/00
C12N 9/00
C12N 9/06
C07C 13/28
US Classification:

435128, 435 41, 435183, 435191, 585352
Abstract:

A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure.

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor
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US Patent:

8361761, Jan 29, 2013
Filed:

Jun 14, 2012
Appl. No.:

13/523733
Inventors:

Michael Politino - Syracuse NY, US
Matthew M. Cadin - Auburn NY, US
Paul M. Skonezny - Baldwinsville NY, US
Jason G. Chen - Manlius NY, US
Assignee:

Bristol Myers-Squibb Company - Princeton NJ
International Classification:

C12P 13/00
C12P 1/00
C12N 9/06
C07C 13/28
US Classification:

435128, 435 41, 435183, 435191, 585352
Abstract:

A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure.

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor
view source
US Patent:

20050260712, Nov 24, 2005
Filed:

Apr 12, 2005
Appl. No.:

11/104015
Inventors:

Michael Politino - Syracuse NY, US
Matthew Cadin - Auburn NY, US
Paul Skonezny - Baldwinsville NY, US
Jason Chen - Manlius NY, US
International Classification:

C12P021/06
C07H021/04
C12N009/06
C12N015/74
C12N001/21
C12P013/04
US Classification:

435069100, 435191000, 435252300, 435471000, 536023200, 435108000
Abstract:

A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor
view source
US Patent:

20130204012, Aug 8, 2013
Filed:

Jan 4, 2013
Appl. No.:

13/734650
Inventors:

Bristol-Myers Squibb Company - Princeton NJ, US
Matthew M. Cadin - Auburn NY, US
Paul M. Skonezny - Baldwinsville NY, US
Jason G. Chen - Manlius NY, US
Assignee:

BRISTOL-MYERS SQUIBB COMPANY - Princeton NJ
International Classification:

C07D 209/52
US Classification:

548452
Abstract:

A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structureprepared by subjecting an acid of the structureto reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2with di-tert-butyl dicarbonate to form the BOC-protected amine.

Matthew M Cadin