Mason E Vail

US Patent:

20070233441, Oct 4, 2007

Filed:

Sep 23, 2005

Appl. No.:

11/234413

Inventors:

William Crowley - Eagle ID, US
Ullysses Eoff - Meridian ID, US
Cap Petschulat - Boise ID, US
Mason Vail - Nampa ID, US
Richard Newman - Meridian ID, US
Timothy Andersen - Boise ID, US
Timothy Otter - Caldwell ID, US
Robert Davis - Boise ID, US

Assignee:

Crowley Davis Research, Inc. - Eagle ID

International Classification:

G06G 7/48
G06G 7/58

US Classification:

703011000

Abstract:

A method system, and apparatus for virtual modeling of biological tissue yields virtual multicellular individuals that exhibit adaptive emergent functionality in response to environmental stimuli. Virtual environmental parameters and cells with genomes are generated, and modified by genetic operations. Cells are developed into generations of multicellular individuals, which are evaluated and selected via evolutionary search according to fitness criteria, and individuals exhibiting adaptive emergent functionality, such as self-repair, are developed and identified.

US Patent:

20090070087, Mar 12, 2009

Filed:

Sep 7, 2007

Appl. No.:

11/899927

Inventors:

Richard D. Newman - Meridian ID, US
Timothy L. Anderson - Boise ID, US
Ullysses A. Eoff - Nampa ID, US
Marc G. Footen - Nampa ID, US
Timothy Otter - Caldwell ID, US
Cap Petschulat - Boise ID, US
Mason E. Vail - Nampa ID, US
David G. Zuercher - Boise ID, US

International Classification:

G06G 7/48

US Classification:

703 11

Abstract:

A multi-cellular virtual tissue having the emergent properties of self-repair, adaptive response to an altered environment, or tissue differentiation, and a method of generating the tissue by computer modeling are disclosed. The tissue is formed of a plurality of virtual cells, each having a heritable virtual genome containing a set of virtual genes relating to each of (a1) intercellular adhesion, (a2) cell division, (a3) cell growth, (a4) intercellular signaling, and (a5) the state of one cell relative to an adjacent cell. In forming the tissue, the sequential operation and actions of the genes are guided by (1) chemical-interaction rules that govern the extra-genetic behavior of one or more molecules placed or produced in the environment, (2) action rules that specify a cell's adhesion, growth, or cell-division condition, in response to molecules produced by a cell's genes relating to intercellular adhesion, cell growth, or cell division, respectively, and (3) physical-interaction rules that govern how a cell will move in response to its own growth or division or the growth or division of neighboring cells.

US Patent:

20100153082, Jun 17, 2010

Filed:

Sep 4, 2009

Appl. No.:

12/554870

Inventors:

Richard D. Newman - Meridian ID, US
Timothy L. Andersen - Boise ID, US
Ullysses A. Eoff - Nampa ID, US
Marc G. Footen - Nampa ID, US
Jeffrey W. Habig - Boise ID, US
Timothy Otter - Caldwell ID, US
Cap C. Petschulat - Berkeley CA, US
Mason E. Vail - Nampa ID, US
David G. Zuercher - Boise ID, US

International Classification:

G06G 7/60

US Classification:

703 11

Abstract:

Systems and methods are provided herein that enable computer-implemented modeling of a biological event. Cell-based models produced from such systems and methods are also disclosed. In some embodiments, systems and methods are provided for cell-centric simulation with accommodating environment feedback. In one embodiment, a computer-implemented method of modeling a biological event can include receiving configurable simulation information and initializing an ontogeny engine to an initial step boundary in accordance with the configurable simulation information. The method can also include advancing the ontogeny engine from a current step boundary to a next step boundary in accordance with the configurable simulation information and the current step boundary. The advancing can include performing a metabolizeCell function. The method can further include continuing the advancing until a halting condition is encountered. In some embodiments, simulation of biological events includes modeling biological processes, such as development of ECM, multicellular tissue and differentiation of pluripotent cells.

US Patent:

20100305929, Dec 2, 2010

Filed:

Mar 5, 2010

Appl. No.:

12/718873

Inventors:

Timothy L. Andersen - Boise ID, US
Ullysses A. Eoff - Nampa ID, US
Marc G. Footen - Nampa ID, US
Richard D. Newman - Meridian ID, US
Timothy Otter - Caldwell ID, US
Cap C. Petschulat - Berkeley CA, US
Mason E. Vail - Nampa ID, US
David G. Zuercher - Boise ID, US

International Classification:

G06G 7/60

US Classification:

703 11

Abstract:

Systems and methods are provided herein that enable computer-implemented modeling of a biological event. Cell-based models produced from such systems and methods are also disclosed. In some embodiments, systems and methods are provided for cell-centric simulation with accommodating environment feedback. In one embodiment, a computer-implemented method of modeling a biological event can include receiving configurable simulation information and initializing an ontogeny engine to an initial step boundary in accordance with the configurable simulation information. The method can also include advancing the ontogeny engine from a current step boundary to a next step boundary in accordance with the configurable simulation information and the current step boundary. The advancing can include performing a stepCells function. The method can further include continuing the advancing until a halting condition is encountered. In some embodiments, simulation of biological events includes modeling biological processes, such as development of multicellular tissue and differentiation of pluripotent cells.