Martin S Edelstein

US Patent:

7563890, Jul 21, 2009

Filed:

Aug 18, 2005

Appl. No.:

11/207383

Inventors:

Timothy B. Karpishin - Castro Valley CA, US
Josh Kriesel - San Francisco CA, US
Grant Merrill - San Francisco CA, US
Donald B. Bivin - Oakland CA, US
Thomas H. Smith - San Carlos CA, US
Martin Stuart Edelstein - Foster City CA, US

Assignee:

Covalent Partners, LLC - Hayward CA

International Classification:

C07D 487/00
C07D 491/00
C07D 513/00

US Classification:

540476

Abstract:

Certain amphiphilic modules comprising 3-24 synthons are provided herein. Each synthon is independently selected from aryl, heteroaryl, alicyclic, and heteroalicyclic substituents, wherein each synthon selected is bonded to the next through a linker to form a closed ring that defines a nanopore. One or more lipophilic moieties and one or more hydrophilic moieties are bonded to one or more of the synthons, resulting in the formation of the desired amphiphilic modules. Those modules may be subsequently linked to one another to form two-dimensional close-packed planar arrays, referred to as nanomembranes. Nanomembranes may be useful in filtering certain ionic species from a solution. Selective passage of particular species is determined, in part, by the size of the module's nanopore and the nature of the lipophilic/hydrophobic species attached thereto. Also provided are methods of making and using amphiphilic modules and nanomembranes.

US Patent:

7767810, Aug 3, 2010

Filed:

Aug 8, 2005

Appl. No.:

11/199913

Inventors:

Joshua W. Kriesel - San Francisco CA, US
Timothy B. Karpishin - Castro Valley CA, US
Donald B. Bivin - Oakland CA, US
Grant Merrill - San Francisco CA, US
Martin S. Edelstein - Foster City CA, US
Thomas H. Smith - San Carlos CA, US
Jeffery A. Whiteford - Belmont CA, US
Robert T. Jonas - Palo Alto CA, US

Assignee:

Covalent Partners, LLC - Hayward CA

International Classification:

C07D 487/00

US Classification:

540471

Abstract:

Certain macrocyclic modules comprising 3-24 synthons are provided herein. Each synthon is independently selected from cyclic substituents, wherein each synthon selected is bonded to the next through a linker to form a closed ring that defines a pore. One or more lipophilic moieties and one or more hydrophilic moieties are bonded to one or more of the synthons, resulting in the formation of the desired macrocyclic modules. Those modules may be subsequently linked to one another to form selectively-permeable membranes. Membranes comprising macrocyclic modules may be useful in filtering certain molecular species from a solution. Selective passage of particular species is determined, in part, by the size of the module's pore and the nature of the lipophilic/hydrophobic species attached thereto. Also provided are methods of making and using macrocyclic modules and membranes.

US Patent:

8110679, Feb 7, 2012

Filed:

Jul 31, 2008

Appl. No.:

12/183469

Inventors:

Joshua W. Kriesel - San Francisco CA, US
Timothy B. Karpishin - Castro Valley CA, US
Donald B. Bivin - Oakland CA, US
Grant Merrill - San Francisco CA, US
Martin S. Edelstein - Foster City CA, US
Thomas H. Smith - San Carlos CA, US
Jeffery A. Whiteford - Belmont CA, US
Robert T. Jonas - Palo Alto CA, US
Mark Micklatcher - Hayward CA, US
Serena Joshi - San Jose CA, US

Assignee:

Covalent Partners LLC - Burlingame CA

International Classification:

C07D 291/00

US Classification:

540474, 540460, 540467, 540471, 544238, 544294, 544333, 502 64, 210636

Abstract:

Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.

US Patent:

20030199688, Oct 23, 2003

Filed:

Aug 23, 2002

Appl. No.:

10/226400

Inventors:

Josh Kriesel - San Francisco CA, US
Timothy Karpishin - Castro Valley CA, US
Donald Bivin - Oakland CA, US
Grant Merrill - San Francisco CA, US
Martin Stuart Edelstein - Foster City CA, US
Thomas Smith - San Carlos CA, US
Jeffery Whiteford - Belmont CA, US
Robert Thomas Jonas - Palo Alto CA, US

International Classification:

C07D291/00

US Classification:

540/454000, 540/460000, 540/467000, 540/471000

Abstract:

Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.

US Patent:

20040034223, Feb 19, 2004

Filed:

Feb 7, 2002

Appl. No.:

10/071377

Inventors:

Timothy Karpishin - Castro Valley CA, US
Josh Kriesel - San Francisco CA, US
Grant Merrill - San Francisco CA, US
Donald Bivin - Oakland CA, US
Thomas Smith - San Carlos CA, US
Martin Edelstein - Foster City CA, US

Assignee:

CoValent Partners, LLC.

International Classification:

C07D221/12
C07D451/02
C07D211/06

US Classification:

544/238000, 544/294000, 544/333000, 544/349000, 546/124000, 546/133000, 546/195000, 546/203000, 546/108000, 548/528000, 549/059000, 549/060000

Abstract:

The present invention relates to the preparation of synthons that are used to form modules that, in turn, are used to form two-dimensional close-packed planar arrays, referred to as nanomembranes. In a presently preferred embodiment, a nanomembrane herein constitutes a filter.

US Patent:

20040260085, Dec 23, 2004

Filed:

Feb 7, 2003

Appl. No.:

10/359894

Inventors:

Joshua Kriesel - San Francisco CA, US
Timothy Karpishin - Castro Valley CA, US
Donald Bivin - Oakland CA, US
Grant Merrill - San Francisco CA, US
Martin Edelstein - Foster City CA, US
Thomas Smith - San Carlos CA, US
Jeffery Whiteford - , US
Robert Jonas - Palo Alto CA, US
Mark Micklatcher - Hayward CA, US
Serena Joshi - Cupertino CA, US

International Classification:

C07D487/14

US Classification:

540/471000

Abstract:

Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a substrate. A nanofilm may also be prepared by coupling the oriented macrocyclic modules to provide a membrane.

US Patent:

20100152438, Jun 17, 2010

Filed:

Jul 16, 2009

Appl. No.:

12/504610

Inventors:

Timothy B. Karpishin - Castro Valley CA, US
Josh kriesel - San Francisco CA, US
Grant Merrill - San Francisco CA, US
Donald B. Bivin - Oakland CA, US
Thomas H. Smith - San Carlos CA, US
Martin Stuart Edelstein - Foster City CA, US

International Classification:

C07D 259/00

US Classification:

540460, 540472

Abstract:

The present invention relates to the preparation of synthons that are used to form modules that, in turn, are used to form two-dimensional close-packed planar arrays, referred to as nanomembranes. In a presently preferred embodiment, a nanomembrane herein constitutes a filter.