Marta Manning

US Patent:

7393443, Jul 1, 2008

Filed:

Aug 23, 2004

Appl. No.:

10/924235

Inventors:

Wilfredo Colón - Cohoes NY, US
Marta Manning - Troy NY, US

Assignee:

Rensselaer Polytechnic Institute - Troy NY

International Classification:

B01D 59/42
G01N 31/00

US Classification:

204456, 436 2

Abstract:

The present invention provides a fast and efficient means for identifying kinetically stable proteins. As used herein the term “kinetically stable protein” means a protein that is trapped in a specific conformation due to an unusually high unfolding barrier that results in very slow unfolding rates. The present inventors are the first to discover the existence of a correlation between kinetic stability and SDS-induced denaturation. Thus, the invention provides methods for identifying kinetically stable proteins comprising the step of testing the proteins for resistance to denaturation by SDS. In one embodiment, SDS-polyacrylamide gel electrophoresis (SDS-PAGE) is one simple method for quickly identifying and selecting kinetically stable proteins.

US Patent:

20060099647, May 11, 2006

Filed:

Sep 14, 2005

Appl. No.:

11/226072

Inventors:

Wilfredo Colon - Cohoes NY, US
Marta Manning - Troy NY, US

International Classification:

C40B 40/10

US Classification:

435007100

Abstract:

The present invention provides a fast and efficient means for identifying kinetically stable proteins. As used herein the term “kinetically stable protein” means a protein that is trapped in a specific conformation due to an unusually high unfolding barrier that results in very slow unfolding rates. The present inventors are the first to discover the existence of a correlation between kinetic stability and SDS-induced denaturation. Thus, the invention provides methods for identifying kinetically stable proteins comprising the step of testing the proteins for resistance to denaturation by SDS. In one embodiment, SDS-polyacrylamide gel electrophoresis (SDS-PAGE) is one simple method for quickly identifying and selecting kinetically stable proteins. In another embodiment a two-dimensional SDS-PAGE provides a high throughput method for quickly identifying kinetically stable proteins in a sample.

US Patent:

20190145948, May 16, 2019

Filed:

Nov 1, 2018

Appl. No.:

16/350334

Inventors:

Jonathan C. Evans - Midland MI, US
Theodore W. Selby - Midland MI, US
Marta Manning - Midland MI, US
Gregory C. Miiller - Rhodes MI, US
William John VanBergen - Coleman MI, US

Assignee:

Tannas Company - Midland MI

International Classification:

G01N 33/28

Abstract:

Elevated temperature liquid testing apparatus and methodology in which a thin film of test liquid and a reactant/control gas are provided about the top of a depositor member that is surrounded by a special mantle, for example, a substantially cylindrically walled glass mantle. As an oxidative engine oil test, it may mimic turbocharger conditions of a modern internal combustion engine. For example, employing moist air, the apparatus can test a thin film of engine oil for oxidation deposits at a predetermined temperature, say, 285 C., 290 C., or cycled between 285 C. or 290 C. and 320 C. or 330 C.

US Patent:

20180003692, Jan 4, 2018

Filed:

Apr 7, 2017

Appl. No.:

15/731024

Inventors:

Jonathan C. Evans - Midland MI, US
Theodore W. Selby - Midland MI, US
Marta Manning - Midland MI, US
Derrick D. Hilliker - Midland MI, US
Michael A. Habitz - Saginaw Township MI, US

Assignee:

Tannas Company - Midland MI

International Classification:

G01N 33/28
C10M 105/00
C10M 121/04
C10M 105/32
C10M 113/06

Abstract:

Grease wear test device includes a body in a form of a collar having an outer surface, a first side and an opposing second side, which are open to form a hollow, open channel through the body, which has a center axis, into which opposing vee blocks can be inserted; and perpendicular to the center axis, a pair of opposing holes through and open to the outer surface of the body and the cylindrical inside wall, through which a cylindrical test journal (falex pin) can be inserted for contact in general with opposing vee-shaped channels of the inserted, opposing vee blocks, and for rotation during testing. The device can be used to modify a falex pin and vee block device, to receive and contain a small sample of grease or another organic paste product for testing such as a modified version of an ASTM D2670 test method for measuring wear properties of fluid lubricants (falex pin and vee block method).

US Patent:

20170284994, Oct 5, 2017

Filed:

Apr 5, 2017

Appl. No.:

15/731004

Inventors:

Jonathan C. Evans - Midland MI, US
Theodore W. Selby - Midland MI, US
Marta Manning - Midland MI, US

Assignee:

Tannas Company - Midland MI

International Classification:

G01N 33/28
C10M 113/06
C10M 169/02
C10M 109/00
C10M 121/04

Abstract:

Effects of Oxygen on grease or another organic paste product can be evaluated with a modified version of the ASTM D942 test methodology for oxidation stability of lubricating greases or other organic paste products by employment of an oxidation pressure vessel, in which at least one of (A) a very small sample of the grease or other organic paste product is deployed for testing within the oxidation pressure vessel such that the sample has an enhanced surface area to mass ratio, and (B) a temperature other than about 99 C. is employed during the testing. In general, the testing is carried out under oxidation pressure conditions. The sample may be evaluated with respect to Oxygen uptake. Additional technique(s) directed to oxidation and/or other properties of the sample may be carried out before to after any Oxygen uptake evaluation, for example, FTIR analysis and/or ATR-FTIR analysis.