Mario D Delmar

Author:

Mario Delmar

ISBN #:

0879934174

Author:

Mario Delmar

ISBN #:

3540407634

US Patent:

20100298225, Nov 25, 2010

Filed:

Jul 14, 2008

Appl. No.:

12/669351

Inventors:

Bjarne Due Larsen - Roskilde, DK
Mario Delmar - Ann Arbor MI, US
Steven M. Taffet - Syracuse NY, US
Wanda Coombs - Syracuse NY, US

International Classification:

A61K 38/16
C07K 14/00
C07K 7/06
A61P 9/00
C07K 7/08
A61P 29/00
A61K 38/10
A61K 38/08
A61P 27/16
A61P 13/10
A61P 13/12
A61P 25/00
A61P 37/06
A61P 35/00
A61P 11/00

US Classification:

514 154, 530326, 530328, 530330, 530327, 530324, 514 213, 514 215, 514 218, 514 216, 514 214, 514 193, 514 183, 514 177

Abstract:

Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).

US Patent:

20120101255, Apr 26, 2012

Filed:

Oct 24, 2011

Appl. No.:

13/279703

Inventors:

Mario Delmar - Syracuse NY, US
Steven M. Taffet - Syracuse NY, US
Bjarne Due Larsen - Roskilde, DK

Assignee:

Zealand Pharma A/S - Glostrup
The Research Foundation of State University of New York - Albany NY

International Classification:

C07K 14/00
C07K 2/00

US Classification:

530324, 530350, 530300

Abstract:

The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT.

US Patent:

20120264693, Oct 18, 2012

Filed:

Jun 11, 2010

Appl. No.:

13/377773

Inventors:

Mario Delmar - Ann Arbor MI, US
Steven M. Taffet - Syracuse NY, US
Wanda Coombs - New York NY, US
Vandana Verma - Ann Arbor MI, US
Bjarne Due Larsen - Roskilde, DK

Assignee:

Zealand Pharma A/S - Glostrup
The Regents of the University of Michigan - Ann Arbor MI
The Research Foundation of State Univesity of New York - Albany NY

International Classification:

A61K 38/12
C12N 5/07
A61P 9/00
A61P 17/00
A61P 27/02
A61P 13/10
A61P 19/10
A61P 13/12
A61P 35/00
A61P 19/00
A61P 13/02
C07K 7/64
A61P 25/00

US Classification:

514 154, 530317, 514 211, 435375, 514 164, 514 186, 514 208, 514 177, 514 169, 514 193

Abstract:

Compounds capable of modulating intracellular gap junctional communication, as well as their use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC) 1 are disclosed.

US Patent:

20090075291, Mar 19, 2009

Filed:

Jul 14, 2008

Appl. No.:

12/172355

Inventors:

Mario DELMAR - Syracuse NY, US
Steven M. TAFFET - Syracuse NY, US
Bjarne Due LARSEN - Roskilde, DK

Assignee:

The Research Foundation of State University of New York - Albany NY
Zealand Pharma A/S - Glostrup

International Classification:

G01N 33/53
C07K 14/00
G01N 33/566

US Classification:

435 71, 530324, 436501

Abstract:

The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A]where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XRXPXwhere each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A-Awhere each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XRXPXwhere each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.

US Patent:

20140273003, Sep 18, 2014

Filed:

Mar 13, 2014

Appl. No.:

14/209704

Inventors:

- New York NY, US
David Fenyo - New York NY, US
Dylan Reid - Rancho Cucamonga CA, US
Mario Delmar - New York NY, US
Marina Cerrone - New York NY, US

Assignee:

New York University - New York NY

International Classification:

G01N 33/50
G06F 19/12

US Classification:

435 71, 702 19

Abstract:

The present invention relates generally ultrasensitive assays for use in diagnostics and in methods of drug screening and personalizing therapy for an individual patient. Specifically, the present invention relates to improved imaging and computational methods for detecting molecular phenotypes.