Louis A Magnarelli

US Patent:

55230890, Jun 4, 1996

Filed:

Jun 22, 1993

Appl. No.:

8/079601

Inventors:

Sven Bergstrom - Umea, SE
Alan G. Barbour - San Antonio TX
Louis A. Magnarelli - Durham CT

Assignee:

Symbicom Aktiebolag

International Classification:

A61K 3900
A61K 3902

US Classification:

4242621

Abstract:

B fraction of Borrelia burgdorferi, methods for preparing the B fraction, and compositions containing the B fraction, are disclosed and claimed.

US Patent:

62037986, Mar 20, 2001

Filed:

Jun 6, 1995

Appl. No.:

8/470627

Inventors:

Sven Bergstrom - Umea, SE
Alan G. Barbour - San Antonio TX
Louis A. Magnarelli - Durham CT

Assignee:

Symbicom Aktiebolag - Umea

International Classification:

A61K 3902
A61K 3938
G01N 3353
C07K 100

US Classification:

4242341

Abstract:

Disclosed and claimed are: substantially pure lipidated OspA protein, compositions containing substantially pure lipidated OspA protein, immunogenic fragments of OspA, compositions containing immunogenic fragments of OspA, polypeptides containing an immunogenic fragment or epitopic region of OspA, and methods for making and using such proteins, fragments, and polypeptides.

US Patent:

55829902, Dec 10, 1996

Filed:

Oct 3, 1994

Appl. No.:

8/320416

Inventors:

Sven Bergstrom - Umea, SE
Alan G. Barbour - San Antonio TX
Louis A. Magnarelli - Durham CT

Assignee:

Symbicom Aktiebolag

International Classification:

C12Q 168
C12P 1934
C07H 2104

US Classification:

435 6

Abstract:

Disclosed and claimed are isolated nucleic acid molecules, such as DNA encoding Borrelia burgdorferi OspA, vectors containing the nucleic acid molecules, and methods for diagnosing Borrelia burgdorferi infection employing such nucleic acid molecules. The isolated nucleic acid molecule can be an isolated DNA molecule encoding the 31 kD OspA protein of New York strain B31. The isolated nucleic acid molecule also can be an isolated DNA molecule encoding Borrelia burgdorferi OspA and a signal peptide which contains an amino acid recognition sequence. The recognition sequence can be L-z-z-C, where each z independently designates a small, neutral amino acid, such as isoleucine or alanine. The recognition sequence can also be L-I-x-C where x is a non-charged amino acid residue, such as alanine. Further, the isolated nucleic acid molecule can be an isolated DNA molecule encoding Borrelia burgdorferi OspA and which includes a 5'-flanking region containing at least one promoter sequence for expression of the OspA.

US Patent:

61839868, Feb 6, 2001

Filed:

Jun 6, 1995

Appl. No.:

8/466393

Inventors:

Sven Bergstrom - Umea, SE
Alan G. Barbour - San Antonio TX
Louis A. Magnarelli - Durham CT

Assignee:

Symbicom Aktiebolag - Umea

International Classification:

C12P 2106

US Classification:

435 691

Abstract:

Disclosed and claimed is an isolated DNA molecule having a nucleotide sequence encoding substantially pure OspA, as well as vectors containing such DNA, uses of such DNA, and compositions containing such vectors.

US Patent:

60837225, Jul 4, 2000

Filed:

Jun 6, 1995

Appl. No.:

8/471019

Inventors:

Sven Bergstrom - Umea, SE
Alan G. Barbour - San Antonio TX
Louis A. Magnarelli - Durham CT

Assignee:

Symbicom AB - Ume.ang.

International Classification:

C12P 2106
C12P 1934
C07H 2104

US Classification:

435 693

Abstract:

Disclosed and claimed are Lyme disease vaccines and methods for making and using them. The vaccines include a vector containing DNA encoding OspA or an immunogenic fragment thereof or such DNA encoding OspA or an immunogenic fragment thereof which has been modified by substitution, addition, insertion or deletion of one or more nucleotides, whereby the DNA when expressed results in OspA, or an immunogenic fragment thereof, or a polypeptide having the immunological activity of OspA or the fragment thereof.