Takeda San Francisco Dec 2008 - Jul 2012
Director, Antibody Technologies
XOMA (US) LLC May 2003 - Nov 2008
Director, Antibody Discovery and Engineering
Abgenix, Inc. Jan 2000 - Apr 2003
Scientist
UCSF - San Francisco Bay Area Sep 1993 - Sep 1999
Postdoctoral fellow
Education:
Università degli Studi di Urbino 'Carlo Bo'
Doctoral degree, Biochemistry
Skills:
Drug Discovery Biotechnology Monoclonal Antibodies Antibodies Assay Development
Us Patents
Method Of Treating Or Preventing An Il-1 Related Disease Or Condition
Linda Masat - Oakland CA, US Mary Haak-Frendscho - Newark CA, US Gang Chen - San Diego CA, US Arnold Horwitz - San Leandro CA, US Marina Roell - Concord CA, US
Assignee:
XOMA Technology Ltd. - Berkeley CA
International Classification:
C12N 5/10 C12N 15/13 C12N 15/63
US Classification:
536 2353, 435325, 4352523, 4353201
Abstract:
Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO:28, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide is provided. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Method Of Treating An Il-1 Related Inflammatory Disease Or Condition
Linda Masat - Oakland CA, US Mary Haak-Frendscho - Newark CA, US Gang Chen - San Diego CA, US Arnold Horwitz - San Leandro CA, US Marina Roell - Concord CA, US
Assignee:
XOMA Technology Ltd. - Berkeley CA
International Classification:
A61K 39/395
US Classification:
4241411, 4241451, 4241391
Abstract:
Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO:28, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide is provided. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Linda Masat - Walnut Creek CA, US Mary Haak-Frendscho - Newark CA, US Arnold H. Horwitz - San Leandro CA, US Gang Chen - San Diego CA, US Marina Roell - Concord CA, US
Assignee:
Xoma Technology Ltd. - Berkeley CA
International Classification:
C07K 16/24 A61K 39/395
US Classification:
424 852, 5303871, 5303881
Abstract:
An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 8 and SEQ ID NO: 9, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Il-1Β Binding Antibodies And Binding Fragments Thereof
Linda Masat - Walnut Creek CA, US Mary Haak-Frendscho - Newark CA, US Arnold H. Horwitz - San Leandro CA, US Gang Chen - San Diego CA, US Marina Roell - Concord CA, US
Assignee:
XOMA Technology Ltd. - Berkeley CA
International Classification:
C07K 16/24 A61K 39/395
US Classification:
424 852, 5303871, 5303881
Abstract:
An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Method Of Treating An Il-1 Related Autoimmune Disease Or Condition
Linda Masat - Walnut Creek CA, US Mary Haak-Frendscho - Newark CA, US Arnold H. Horwitz - San Leandro CA, US Gang Chen - San Diego CA, US Marina Roell - Concord CA, US
Assignee:
Xoma Technology Ltd. - Berkeley CA
International Classification:
A61K 39/395
US Classification:
4241451, 4241301, 4241391, 4241411, 514885
Abstract:
Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Linda Masat - Walnut Creek CA, US Mary Haak-Frendscho - Newark CA, US Arnold H. Horwitz - San Leandro CA, US Gang Chen - San Diego CA, US Marina Roell - Concord CA, US
Assignee:
Xoma Technology Ltd. - Berkeley CA
International Classification:
A61K 39/395
US Classification:
4241451, 4241301, 4241391, 4241411, 514885
Abstract:
Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.
Jason Damiano - Emeryville CA, US Mohammad Luqman - Emeryville CA, US Daniel Bedinger - Vacaville CA, US Linda Masat - Oakland CA, US Amer Mirza - San Francisco CA, US Genevieve Nonet - Berkeley CA, US
Assignee:
Novartis AG - Basel Xoma Technology Ltd. - Berkeley CA
PRLR-specific antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating cancer.
Linda Masat - Walnut Creek CA, US Mary Haak-Frendscho - Newark CA, US Arnold H. Horwitz - San Leandro CA, US Gang Chen - San Diego CA, US Marina Roell - Concord CA, US
Assignee:
XOMA Technology Ltd. - Berkeley CA
International Classification:
C07K 16/24 A61K 39/395
US Classification:
424 852, 5303871, 5303881
Abstract:
An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.