Linda J Chernesky

US Patent:

55167950, May 14, 1996

Filed:

Sep 12, 1994

Appl. No.:

8/304745

Inventors:

Joseph F. Dellaria - Lindenhurst IL
Linda J. Chernesky - Arlington Heights IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31335
C07D31726

US Classification:

514467

Abstract:

Compounds of the structure ##STR1## where R. sup. 1 is alkyl of one to four carbon atoms and R. sup. 2 is selected from (a) alkenyl of one to four carbon atoms, (b) ##STR2## (c) ##STR3## and (d) ##STR4## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

US Patent:

54847869, Jan 16, 1996

Filed:

Aug 24, 1993

Appl. No.:

8/111090

Inventors:

Joseph F. Dellaria - Lindenhurst IL
Anwer Basha - Lake Forest IL
Lawrence A. Black - Vernon Hills IL
Linda J. Chernesky - Arlington Heights IL
Wendy Lee - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3135
A61K 31495
C07D31500
C07D23904

US Classification:

514256

Abstract:

Compounds of structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R. sup. 5 and R. sup. 6 are independently selected from hydrogen and alkyl, or R. sup. 5 and R. sup. 6, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## L. sup. 1 and L. sup. 2 are independently selected from a valence bond, alkylene, propenylene, and propynylene, R. sup. 1, R. sup. 2, R. sup. 3, and R. sup. 4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is oxygen, >NR. sup. 9 where R. sup. 9 is hydrogen or alkyl, or ##STR4## where n=0, 1, or 2, and A is selected from ##STR5## inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

US Patent:

54079594, Apr 18, 1995

Filed:

Nov 12, 1993

Appl. No.:

8/152115

Inventors:

Joseph F. Dellaria - Lindenhurst IL
Anwer Basha - Lake Forest IL
Lawrence A. Black - Vernon Hills IL
Linda J. Chernesky - Arlington Heights IL
Wendy Lee - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3117
C07C27506
C07C27530

US Classification:

514598

Abstract:

Compounds of structure ##STR1## where W is selected from the group consisting of ##STR2## where Q is oxygen or sulfur, R. sup. 7 and R. sup. 8 are independently selected from hydrogen and alkyl, or R. sup. 7 and R. sup. 8, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## L. sup. 1 and L. sup. 2 are independently selected from a valence bond, alkylene, propenylene, and propynylene; R. sup. 1, R. sup. 2, R. sup. 3, and R. sup. 4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is oxygen, >NR. sup. 11, where R. sup. 11 is hydrogen or alkyl, or ##STR4## where n=0, 1, or 2; and R. sup. 5 and R. sup. 6 are alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

US Patent:

54460620, Aug 29, 1995

Filed:

Nov 12, 1993

Appl. No.:

8/152569

Inventors:

Joseph F. Dellaria - Lindenhurst IL
Anwer Basha - Lake Forest IL
Lawrence A. Black - Vernon Hills IL
Linda J. Chernesky - Arlington Heights IL
Wendy Lee - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3135
C07D30910
C07D40510

US Classification:

514459

Abstract:

Compounds of the structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R. sup. 6 and R. sup. 7 are hydrogen or alkyl, or R. sup. 6 and R. sup. 7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## Z is --CH. sub. 2 --, oxygen, sulfur, or --NR. sup. 9, L. sup. 1 and L. sup. 2 are selected from a valence bond, alkylene, propenylene, and propynylene; R. sup. 1 and R. sup. 2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR. sup. 10, and ##STR4## L. sup. 3 is selected from alkylene of one to three carbon atoms, propenylene, propynylene, ##STR5## and R. sup. 3, R. sup. 4, and R. sup. 5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

US Patent:

54321948, Jul 11, 1995

Filed:

May 9, 1994

Appl. No.:

8/236001

Inventors:

Joseph F. Dellaria - Lindenhurst IL
Anwer Basha - Lake Forest IL
Lawrence A. Black - Vernon Hills IL
Linda J. Chernesky - Arlington Heights IL
Wendy Lee - Chicago IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3135
C07D30910

US Classification:

514460

Abstract:

Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R. sup. 6 and R. sup. 7 are hydrogen or alkyl, or R. sup. 6 and R. sup. 7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R. sup. 8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH. sub. 2 --, oxygen, sulfur, or --NR. sup. 9 where R. sup. 9 is hydrogen or alkyl, L. sup. 1 and L. sup. 2 are selected from a valence bond, alkylene, propenylene, and propynylene, R. sup. 1, R. sup. 2, R. sup. 3, and R. sup. 4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR. sup. 10, where R. sup.

US Patent:

54750091, Dec 12, 1995

Filed:

Sep 12, 1994

Appl. No.:

8/304066

Inventors:

Linda J. Chernesky - Arlington Heights IL
Joseph F. Dellaria - Lindenhurst IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 3147
C07D21514

US Classification:

514312

Abstract:

Compounds of the structure ##STR1## where Ar. sup. 1 is selected from optionally substituted carbocyclic aryl; optionally substituted 5- or 6-membered heterocyclic aryl; optionally substituted 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms; optionally substituted benzo[b]furyl; optionally substituted benzo[b]thienyl; ##STR2## L. sup. 1 is a valence bond, alkylene, propenylene, or propynylene; Y is oxygen, >NR. sup. 5, or >S(O)n; Ar. sup. 2 is optionally substituted phenyl; L. sup. 2 is ##STR3## and R. sup. 1 and R. sup. 2 are alkyl, or taken together define a group of formula ##STR4## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.