Leonid B Margolis

age ~76

from Kensington, MD

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Leonid Margolis Phones & Addresses

In Vitro Model For Hiv And Other Viral Diseases
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US Patent:

6562586, May 13, 2003
Filed:

Jun 12, 2000
Appl. No.:

09/591805
Inventors:

Robert M. Hoffman - Lahoya CA
Leonid B. Margolis - Bethesda MD
Joshua Zimmerberg - Bethesda MD
Svetlana Glushakova - Bethesda MD
Assignee:

AntiCancer, Inc. - San Diego CA
International Classification:

C12Q 102
US Classification:

435 42, 435 5, 435 72, 435 724, 435 736, 435 34, 435 4052, 435239, 435362, 435366, 435372, 435374, 435373, 435 32, 435325
Abstract:

An in vitro model system for viral infection is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherin the supported tissue block is cultured in a medium whose surface is congruent with the tissue block/matrix interface. The histoculture system can be used to screen for antiviral drugs and to monitor the course of viral diseases.

Use Of Herpesviruses, Herpesvirus Proteins And Nucleic Acids Encoding The Proteins To Inhibit Ccr5-Tropic Hiv-1 Infection And Replication
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US Patent:

7968298, Jun 28, 2011
Filed:

Mar 28, 2002
Appl. No.:

10/473560
Inventors:

Leonid B. Margolis - Kensington MD, US
Jean-Charles Grivel - Frederick MD, US
Paolo Lusso - Milan, IT
Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:

C12Q 1/70
G01N 33/53
US Classification:

435 71, 435 5
Abstract:

It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.

In Vitro Model For Viral Infection And Immune Response
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US Patent:

20030203351, Oct 30, 2003
Filed:

Apr 1, 2003
Appl. No.:

10/405130
Inventors:

Robert Hoffman - La Jolla CA, US
Leonid Margolis - Bethesda MD, US
International Classification:

C12Q001/70
C12Q001/00
US Classification:

435/004000, 435/005000
Abstract:

An in vitro model system for viral infection and for immune response is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherein the supported tissue block is cultured in a medium whose surface is congruent with the tissue block/matrix interface. The histoculture system can be used to screen for antiviral drugs, to monitor the course of viral diseases, and to monitor an immune response to antigen stimulation.

Compounds And Methods For The Treatment Of Viral Infection
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US Patent:

20110184003, Jul 28, 2011
Filed:

Mar 27, 2009
Appl. No.:

12/934769
Inventors:

Leonid Margolis - Kensington MD, US
Jan Balzarini - Leuven, BE
Christopher McGuigan - Cardiff, GB
Andrea Lisco - Washington DC, US
Christophe Vanpouille - Bethesda MD, US
Marco Derudas - Sassari, IT
Assignee:

THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH - Bethesda MD
International Classification:

A61K 31/522
C07D 473/00
A61P 31/14
A61P 31/18
US Classification:

51426338, 544276, 5142633
Abstract:

The invention relates to compounds and methods for treating or preventing a viral infection, by administering a monophosphorylated prodrug of acyclovir or monophosphorylated derivative of an acyclovir prodrug to a subject suffering from or susceptible (to a viral infection, such as HIV infection.

Model For Viral Infection And Immune Response
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US Patent:

6551772, Apr 22, 2003
Filed:

Feb 26, 1999
Appl. No.:

09/259008
Inventors:

Robert M. Hoffman - La Jolla CA
Leonid B. Margolis - Bethesda MD
Assignee:

AntiCancer, Inc. - San Diego CA
International Classification:

C12Q 100
US Classification:

435 4, 435 5, 435372, 435373
Abstract:

An in vitro model system for viral infection and for immune response is comprised of a tissue block from adult tonsil or lymph node supported on a matrix which is flexible and porous and wherein the supported tissue block is cultured in a medium whose surface is congruent with the tissue block/matrix interface. The histoculture system can be used to screen for antiviral drugs, to monitor the course of viral diseases, and to monitor an immune response to antigen stimulation.

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"If valacyclovir's effectiveness against HIV can be confirmed in a larger cohort, it could be added to the mix of drugs used to suppress the virus, and might prove especially helpful in cases in which HIV has developed resistance to other drugs," Leonid Margolis, who was senior author of the st
Date: Mar 16, 2015
Category: Health
Source: Google

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attack, the theory went, HIV-1 could not spread as widely.After conducting laboratory studies with Acyclovir, an earlier sibling drug of Valacyclovir, Leonid Margolis, of the National Institutes of Health (NIH), saw that the medication clearly blocked HIV-1 reproduction, even when HSV-2 was absent.
Date: Mar 15, 2015
Category: Health
Source: Google

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After conducting laboratory studies with Acyclovir, an earlier sibling drug of Valacyclovir, Leonid Margolis, of the National Institutes of Health (NIH), saw that the medication clearly blocked HIV-1 reproduction, even when HSV-2 was absent.
Date: Mar 15, 2015
Category: Health
Source: Google

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The lead author of the study, Leonid Margolis (head of the Section of Intercellular Interactions at the National Institute of Child Health and Human Development in the US), pointed out that the results are highly encouraging and the test should be repeated with larger groups of patients. If new test
Date: Mar 14, 2015
Category: Health
Source: Google