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Marina Nikolaevna Protopopova - Silver Springs MD, US Richard Edward Lee - Cordova TN, US Richard Allan Slayden - Ft. Collins CO, US Elena Bogatcheva - Bethesda MD, US Leo Einck - McLean VA, US
Assignee:
Sequella, Inc. - Rockville MD The United States of America as represented by the Secretary, Department of Health and Human Services - Washington DC
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
Marina Nikolaevna Protopopova - Silver Springs MD, US Richard Edward Lee - Cordova TN, US Richard Allan Slayden - Ft. Collins CO, US Elena Bogatcheva - Bethesda MD, US Leo Einck - McLean VA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC Sequella, Inc. - Rockville MD
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
Methods And Compositions For Determining The Pathogenic Status Of Infectious Agents
Matthew C. Mulvey - Baltimore MD, US Leo Einck - McLean VA, US Katherine Sacksteder - Baltimore MD, US
Assignee:
Sequella, Inc. - Rockville MD
International Classification:
C12Q 1/02 C12Q 1/68 C12Q 1/70
US Classification:
435 5, 435 6, 435 29
Abstract:
Methods and compositions for the detection of disease caused by infectious agents and microbes are provided. In particular, methods and compositions comprising novel combinations of nucleic acid amplification and drug susceptibility technologies are provided. In certain embodiments, the present invention enables the detection of infectious agents and microbes as well as providing information concerning the viability status of the agent or microbe. In one embodiment, the present invention is used for the detection of mycobacterial infections, including, but not limited to, tuberculosis.
Compositions And Methods For Treatment Of Infectious Disease
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis. In certain embodiments, the present invention comprises compositions comprising novel substituted ethylene diamine compounds further comprising antitubercular agents such as rifampicin, isoniazid, pyrazinamide and ethambutol.
Compositions And Methods For The Treatment Of Infectious Diseases
Marina Nikolaevna Protopopova - Silver Spring MD, US Elena Bogatcheva - Bethesda MD, US Leo Einck - McLean VA, US Richard Edward Lee - Cordova TN, US Richard Allan Slayden - Ft. Collins CO, US
Assignee:
The United States of America as Represented by the Secretary, Department of Health and Human Services - Washington DC Sequella, Inc. - Rockville MD
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
Methods And Compositions For Determining The Pathogenic Status Of Infectious Agents
The present invention relates to methods and compositions for improved detection of infectious agents and microbes. In particular, the present invention provides novel methods for detecting infectious agents, providing information about the viability status of such infectious agents and for determining drug susceptibility. In certain embodiments, the present invention employs techniques involving nucleic acid amplification-based microbial identification together with phage-based biological detection of drug resistance. The methods of the invention are suitable for all microbes and infectious agents, including bacterial agents such as.
Marina Protopopova - Silver Spring MD, US Richard Lee - Cordova TN, US Richard Slayden - Ft. Collins CO, US Clifton Barry - Washington DC, US Elena Bogatcheva - Bethesda MD, US Leo Einck - McLean VA, US
International Classification:
A61K031/137 A61K031/695 A61K031/44 A61K031/40
US Classification:
514/649000, 514/063000, 514/357000, 514/408000
Abstract:
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
Marina Protopopova - Silver Springs MD, US Richard Lee - Cordova TN, US Richard Slayden - Ft. Collins CO, US Clifton Barry - Washington DC, US Elena Bogatcheva - Bethesda MD, US Leo Einck - McLean VA, US
International Classification:
A61K031/695 A61K031/44 A61K031/137
US Classification:
514/063000, 514/357000, 514/649000
Abstract:
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.