Apr 2012 to 2000 Deputy COOAvgol Nonwovens Mocksville, NC Jun 2011 to Apr 2012 Plant Manager--USA siteAvgol Nonwovens
Jan 2010 to Jun 2011 General Manager - China siteInternational Textile Group Greensboro, NC Jun 2008 to Jan 2010 Plant Manager--China siteL.W. Packard & Company, Inc Ashland, NH Jan 2005 to Jun 2008 Vice General Manager--China siteL.W. Packard & Company, Inc Ashland, NH Dec 2001 to Jan 2005 Assistant to the PresidentBroad & Suzuki Co., LTD
Jan 1998 to Jan 1999 Marketing ManagerHunan Textile Sales and Supply Co.,LTD. Changsha, CN Jul 1993 to Jan 1998 Sales/Logistics
Education:
Philadelphia University 2001 MBA in FinancePhiladelphia University 2000 MS in MarketingChina Textile University 1989 to 1993 Bachelor of Science in Major Textile Engineering/Minor Industrial Management
Skills:
Strategic planning, Leadership and full P&L Responsibilities, Startup Operation, Create a Quality and Safety Business Culture , China joint ventures, Local Government Relations, Operational excellence/Lean manufacturing, Continuous improvement and KPI management
Jing Cheng - Bejing, CN Lei Wu - San Diego CA Michael J. Heller - Encinitas CA Ed Sheldon - Arcadia CA Jonathan Diver - San Diego CA James P. OConnell - Solana Beach CA Dan Smolko - Jamul CA Shila Jalali - San Diego CA David Willoughby - San Diego CA
We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imaging. We have also released DNA and RNA from the isolated cells electronically and detected specific marker sequences by DNA amplification followed by electronic hybridization to immobilized capture probes. Efforts towards the construction of a âlaboratory-on-a-chipâ system are presented which involves the selection of DNA probes, dyes, reagents and prototyping of the fully integrated portable instrument.
Apparatus And Method For High Throughput Electrorotation Analysis
Jing Cheng - Beijing, CN Junquan Xu - Fujian, CN Xiaoshan Zhu - Hubei, CN Litian Liu - Beijing, CN Xiao-Bo Wang - San Diego CA Lei Wu - San Diego CA
Assignee:
Aviva Biosciences Corporation - San Diego CA
International Classification:
G01R 2708
US Classification:
324693, 324692, 324521, 324515, 349 33, 436806
Abstract:
The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.
Apparatus For Switching And Manipulating Particles And Method Of Use Thereof
Xiao-Bo Wang - San Diego CA Weiping Yang - San Diego CA Junquan Xu - Fujian, CN Jing Cheng - Beijing, CN Lei Wu - San Diego CA
Assignee:
Aviva Biosciences Corporation - San Diego CA
International Classification:
G01N 2726
US Classification:
204547, 204643, 204450
Abstract:
A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.
Apparatus And Method For High Throughput Electrorotation Analysis
The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.
Individually Addressable Micro-Electromagnetic Unit Array Chips In Horizontal Configurations
Lei Wu - San Diego CA Xiaobo Wang - San Diego CA Jing Cheng - Beijing, CN Weiping Yang - San Diego CA YuXiang Zhou - Beijing, CN LiTian Liu - Beijing, CN Junquan Xu - Beijing, CN
The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.
Compositions And Methods For Separation Of Moieties On Chips
The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in a sample based on their dielectric properties. The present invention provides compositions and methods for enhancing the dielectrophoretic separation of one or more moieties in a sample. A first aspect of the present invention is a solution that when mixed with a sample, modifies at least one dielectric property of one or more components of the sample and has a conductivity such that one or more moieties of the sample can be separated using dielectrophoresis. Such solutions can be used in the analysis of samples on chips, and can be used in methods that use binding partners, including microparticles that can be translocated by dielectrophoretic forces, traveling-wave dielectrophoretic forces or magnetic forces.
Apparatuses And Methods For Field Flow Fractionation Of Particles Using Acoustic And Other Forces
This invention relates generally to the field of field-flow-fractionation. In particular, the invention provides apparatuses and methods for the discrimination of matters utilizing acoustic force, or utilizing acoustic force with electrophoretic or dielectrophoretic force, in field flow fractionation.
Methods And Compositions For Identifying Nucleic Acid Molecules Using Nucleolytic Activities And Hybridization
The present invention recognizes that identifying genes expressed during developmental processes, stress responses, and disease states can advance understanding of these biological functions, and can contribute to identifying targets for therapeutic drugs. In addition, the present invention recognizes that rapid and reliable profiling of genetic variations, such as mutations and SNPs, is of increasing importance to diagnostics, prognostics, forensics, heredity determinations, and pharmacogenetics. One aspect of the present invention provides a method of identifying one or more nucleic acid molecules that are expressed under a given set of conditions based on their complementarity to known sequences, or one or more mutations or SNPs in a population of nucleic acid molecules. The method includes: contacting at least one probe nucleic acid molecule with a survey population of nucleic acid molecules under conditions that promote nucleic acid hybridization to generate a probe-survey population mixture of nucleic acid molecules, treating the probe-survey population mixture of nucleic acid molecules with a nucleolytic activity, such that nucleolytic activity-sensitive nucleic acid molecules are digested, and contacting the resulting mixture of nucleolytic activity-protected nucleic acid molecules with a solid support comprising one or more attached nucleic acid molecules to generate attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes, and identifying one or more of the attached nucleic acid molecules or one or more of the nucleolytic activity-protected nucleic acid molecules in one or more attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes.