Leandro C Cerchietti

US Patent:

20110152200, Jun 23, 2011

Filed:

Jun 10, 2009

Appl. No.:

12/737122

Inventors:

Ari M. Melnick - New York NY, US
Leandro Cerchietti - New York NY, US

International Classification:

A61K 38/08
C12N 5/02
C12N 15/63
A61P 35/00
C07K 2/00
C07K 7/06
C07H 21/04

US Classification:

514 194, 435375, 4353201, 514 193, 514 216, 530300, 530328, 536 231

Abstract:

The invention is directed to a compound that binds to a BCL6 lateral groove and prevents binding of a corepressor to the lateral groove. The present invention is further directed to methods for blocking corepressor binding to a BCL6 lateral groove, methods for inhibiting BCL6 repression in a mammalian cell, and methods for treating a mammal with cancer, wherein the cancer requires BCL6 repression. The present invention is further directed to polypeptides comprising a portion of the corepressor binding site for BCL6 and related polynucleotides and vectors.