Laura K Povlich

US Patent:

8005526, Aug 23, 2011

Filed:

Aug 30, 2006

Appl. No.:

11/512479

Inventors:

David C. Martin - Ann Arbor MI, US
Donghwan Kim - Ann Arbor MI, US
Jeffrey L. Hendricks - Ann Arbor MI, US
Laura Povlich - Taylor MI, US
Mohamad Reza Abidian - Ann Arbor MI, US
Matthew Meier - Ann Arbor MI, US

Assignee:

The Regents of The University of Michigan - Ann Arbor MI

International Classification:

A61B 5/04
A61N 1/05

US Classification:

600372, 600377, 600378, 607116, 607137

Abstract:

Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.

US Patent:

20080224099, Sep 18, 2008

Filed:

Feb 27, 2008

Appl. No.:

12/038138

Inventors:

Jinsang Kim - Ann Arbor MI, US
Jae Cheol Cho - Ann Arbor MI, US
Laura K. Povlich - Ann Arbor MI, US
David C. Martin - Ann Arbor MI, US

International Classification:

H01B 1/00
C07D 495/04
C07K 14/48
C07K 14/475
C07K 14/00
C07H 3/00
C07H 21/00

US Classification:

252500, 549 50, 530399, 530402, 536 111, 536 231

Abstract:

An electroconductive carboxylic acid functionalized monomer corresponding to Formula (I), wherein A represents a hydrogen or a carboxyl group. Polymerized monomers of Formula (I) conjugated with a biomolecule result in conjugated PEDOT polymers of Formula (III) wherein A is a hydrogen or a carboxylic acid group and B is a biomolecule selected from the group consisting of a peptide, a protein, a lipid, a carbohydrate and a polynucleotide. The biomolecule conjugated polymers can be disposed onto an electrically conductive substrate wherein the substrate has a first layer of PEDOT polymerized on a surface of the substrate and a second layer of biomolecule conjugated PEDOT polymer of Formula (III) polymerized on the first layer of PEDOT. The first and second layers form a charge transport material in electrical communication with the conductive substrate. The electrically conductive substrate further comprises a dopant.