Kristen L Unverzagt from 1725 Shire Ct, Wheaton, IL 60187, age 61, Phone: 6308719695

In Vitro-Derived Genetically Altered Human Neutrophil Precursor Cells And Methods For Administering The Same
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US Patent:

61466239, Nov 14, 2000
Filed:

Jun 7, 1995
Appl. No.:

8/485579
Inventors:

James G. Bender - Lindenhurst IL
Phillip B. Maples - Waukegan IL
Stephen Smith - Arlington Heights IL
Kristen L. Unverzagt - Palatine IL
Dennis E. Van Epps - Cary IL
Assignee:

Nexell Therapeutics Inc. - Irvine CA
International Classification:

A01N 4304
A61K 3170
C12N 1563
C12N 1500
US Classification:

424 9321
Abstract:

A composition comprising genetically altered human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% human myeloblasts and promyelocytes, which have been derived from neutrophil progenitor cells obtained from peripheral blood, bone marrow or cord blood, and less than about 5% colony forming units (CFU) of at least about 50 cells is provided. An alternative composition comprising genetically altered human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% CD15+CD11b- cells and less than about 5% colony forming units (CFU) of at least about 50 cells also is provided, wherein at least about 60% of the CD15+CD11b- cells are myeloblasts and promyelocytes.

Apparatus For Carrying Flexible Containers And Method Of Transferring Fluids To Containers
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US Patent:

56144121, Mar 25, 1997
Filed:

Sep 8, 1995
Appl. No.:

8/526034
Inventors:

Stephen L. Smith - Arlington Heights IL
James Bender - Lindenhurst IL
Jeffrey Martinson - Mundelein IL
Maureen Loudovaris - Grayslake IL
Orrin D. Mitsven - Lake Villa IL
Kristen L. Unverzagt - Palatine IL
International Classification:

C12M 300
US Classification:

4353051
Abstract:

The present invention provides an apparatus for holding and carrying a plurality of flexible medical containers. The carrier has a rack having a plurality of plates positioned in parallel spaced relation, the plates defining a chamber between each pair of adjacent plates. A plurality of spacer assemblies each extend through the rack to connect the plates and to maintain their spaced relationship. The spacer assemblies are spaced along marginal edges of the rack to define two opposed end walls, a bottom, and an opening to the rack to allow access to each of the chambers. A flange extends from one of the plates and has a hole that allows the carrier to be suspended. The invention further provides for a system for transferring fluids and a method for mixing solutions using the carrier.

Method For The Preparation Of In Vitro-Derived Human Neutrophil Precursor Cells
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US Patent:

57006911, Dec 23, 1997
Filed:

Sep 13, 1996
Appl. No.:

8/707762
Inventors:

James G. Bender - Lindenhurst IL
Phillip B. Maples - Waukegan IL
Stephen Smith - Arlington Heights IL
Kristen L. Unverzagt - Palatine IL
Dennis E. Van Epps - Cary IL
Assignee:

Baxter Healthcare Inc. - Irvine CA
International Classification:

A01N 6300
A61K 3514
C12N 500
C12N 502
US Classification:

435325
Abstract:

A composition of human neutrophil precursor cells is disclosed wherein at least 16% of the cells are human myeloblasts and promyelocytes. The myeloblasts and promyelocytes are derived from human neutrophil progenitor cells that were obtained from peripheral blood, bone marrow or cord blood. The neutrophil precursor cells contain less than 5% colony forming units. Also disclosed are human neutrophil precursor cells made up of about 16% CD15+CD11b- cells and less than 5% colony forming units and methods of preparing these compositions.

Method For Increasing Neutrophil Populations Using In Vitro-Derived Human Neutrophil Precursor Cells
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US Patent:

58884998, Mar 30, 1999
Filed:

Jun 7, 1995
Appl. No.:

8/481894
Inventors:

James G. Bender - Lindenhurst IL
Phillip B. Maples - Waukegan IL
Stephen Smith - Arlington Heights IL
Kristen L. Unverzagt - Palatine IL
Dennis E. Van Epps - Cary IL
Assignee:

Nexell Therapeutics Inc. - Irvine CA
International Classification:

A61K 3528
A61K 3514
C12N 502
C12N 508
US Classification:

424 931
Abstract:

A suspension comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% human myeloblasts and promyeclocytes, which have been derived from neutrophis progenitor cells obtained from peripheral blood, bone marrow or cord blood, and less than about 5% colony forming units (CFU) of at least about 50 cells is provided. An alternative suspension comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% CD15+CD11b- cells and less than about 5% colony forming units (CFU) of at least about 50 cells also is provided, wherein at least about 60% of the CD15+CD11b- cells are myeloblasts and promyelocytes. The suspensions of the invention are useful in methods for increasing neutrophil populations in a patient having a reduced populations of neutrophils.

In-Vitro-Derived Human Neutrophil Precursor Cells
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US Patent:

59553570, Sep 21, 1999
Filed:

Aug 23, 1994
Appl. No.:

8/295501
Inventors:

James G. Bender - Lindenhurst IL
Phillip B. Maples - Waukegan IL
Stephen L. Smith - Arlington Heights IL
Kristen L. Unverzagt - Palatine IL
Dennis E. Van Epps - Cary IL
Assignee:

Nexell Therapeutics Inc. - Irvine CA
International Classification:

C12N 508
US Classification:

435325
Abstract:

The present invention provides a composition of human neutrophil precursor cells having at least 37% myeloblasts and promyeloblasts. Also provided are hematopoietic cell suspensions that have human neutrophil precursor cells and at least one hematopoietic growth factor.

Kristen L Unverzagt