Xiaoqi Chen - Palo Alto CA, US Kang Dai - Albany CA, US Jason Duquette - South San Francisco CA, US Justin N. Huard - Seattle WA, US Kathleen S. Keegan - Bainbridge Island WA, US Zhihong Li - Millbrae CA, US Sarah E. Lively - San Carlos CA, US Lawrence R. McGee - Pacifica CA, US Mark L. Ragains - Fort Worth TX, US Xianghong Wang - Dublin CA, US Margaret F. Weidner - Woodinville WA, US Jian Zhang - Foster City CA, US
Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure:and the definitions of the other variables are provided herein.
Fused Tricyclic Dual Inhibitors Of Cdk 4/6 And Flt3
- THOUSAND OAKS CA, US Kang DAI - Albany CA, US Jason DUQUETTE - Millbrae CA, US Justin N. HUARD - Seattle WA, US Kathleen S. KEEGAN - Bainbridge Island WA, US Zhihong LI - Millbrae CA, US Sarah E. LIVELY - San Carlos CA, US Lawrence R. MCGEE - Pacifica CA, US Mark L. RAGAINS - Forth Worth TX, US Xianghong WANG - Dublin CA, US Margaret F. WEIDNER - Woodinville WA, US Jian ZHANG - Foster City CA, US
International Classification:
C07D 519/00
Abstract:
Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure:and the definitions of the other variables are provided herein.
Novo Nordisk
Senior Associate Scientist
Novo Nordisk May 2015 - Jun 2017
Associate Scientist
Amgen Mar 2011 - Dec 2014
Senior Associate Scientist
Amgen Mar 2008 - Mar 2011
Associate Scientist
Amgen Sep 2005 - Mar 2008
Senior Associate
Education:
University of Washington 2003
Bachelors, Bachelor of Arts
University of Washington 1999 - 2003
Bachelors, Bachelor of Science, Biochemistry
Skills:
Drug Discovery Biotechnology Cell Culture Assay Development Elisa Immunology Cell Monoclonal Antibodies Antibodies Cell Biology In Vivo Western Blotting Flow Cytometry Immunoassays Facs Biomarkers In Vivo Imaging Apoptosis Life Sciences Innovation Teamwork Tumor Modeling Cell Based Assays